主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2014, Vol. 37 ›› Issue (4): 252-254.doi: 10.3969/j.issn.1006-2157.2014.04.009

• 科技之窗 • 上一篇    下一篇

复方补骨脂搽剂对豚鼠白癜风模型作用的实验研究

叶伊琳1, 唐洁1, 刘琴2, 朱立然2, 李莉2   

  1. 1 安徽中医药大学护理学院 安徽 230038;
    2 安徽中医药大学中西医结合临床学院
  • 收稿日期:2013-06-13 出版日期:2014-04-30 发布日期:2014-04-30
  • 通讯作者: 李莉,女,硕士,副教授
  • 作者简介:叶伊琳,女,硕士,副教授,硕士生导师
  • 基金资助:
    安徽省教育厅自然科学基金资助项目(No.KJ2007B327ZC)

Effect of Compound Buguzhi Liniment on vitiligo in guinea pig model

YE Yi-lin1, TANG Jie1, LIU Qin2, ZHU Li-ran2, LI Li2   

  1. 1 College of Nursing, Anhui University of Traditional Chinese Medicine, Anhui 230038;
    2 Clinical College of Integrated Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine
  • Received:2013-06-13 Online:2014-04-30 Published:2014-04-30

摘要: 目的 考察复方补骨脂搽剂对实验性白癜风的作用。方法 用化学脱色法制备白癜风动物模型,用不同剂量复方补骨脂搽剂进行治疗,以复方卡力孜然酊作为阳性对照,考察其对实验性白癜风皮肤黑色素分布、胆碱酯酶与酪氨酸酶活性的影响。结果 复方补骨脂搽剂能促进白癜风模型皮肤色素沉着,基底层细胞及棘层细胞中黑色素增加明显,毛囊内黑色素明显增多,血清胆碱酯酶和酪氨酸酶活性明显增强。结论 复方补骨脂搽剂对实验性白癜风有良好的防治作用。

关键词: 复方补骨脂搽剂, 白癜风, 黑色素, 酪氨酸酶, 豚鼠

Abstract: Objective To investigate the effect of Compound Buguzhi Liniment on vitiligo. Methods The model of vitiligo was established by using chemical decolorization and then treated with Compound Buguzhi Liniment in different doses. Compound Kaliziran Tincture was taken as a positive control drug. The influences of Compound Buguzhi Liniment on distribution of skin melanin and activities of cetylcholinesterase and tyrosinase were observed. Results Compound Buguzhi Liniment promoted skin pigmentation. The level of melanin increased significantly in basal layer cells and spinous layer cells, and hair follicles. The activities of cetylcholinesterase and tyrosinase were improved significantly. Conclusion Compound Buguzhi Liniment has a preventive and therapeutic effect on experimental vitiligo.

Key words: Compound Buguzhi Liniment, vitiligo, melanin, tyrosinase, guinea pigs

中图分类号: 

  • R285.5