主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2015, Vol. 38 ›› Issue (8): 509-514.doi: 10.3969/j.issn.1006-2157.2015.08.001

• 理论研究 •    下一篇

过敏性疾病与肠道菌群失调的相关性及对过敏体质研究的启示*

杨菲, 王济, 王琦#   

  1. 北京中医药大学基础医学院中医体质与生殖医学研究中心 北京 100029
  • 收稿日期:2015-02-28 出版日期:2015-08-30 发布日期:2015-08-30
  • 通讯作者: 王琦,男,教授,博士生导师 ,E-mail:wangqi710@126.com
  • 作者简介:杨菲,女,在读硕士生
  • 基金资助:
    国家自然科学基金面上项目(No.81273611,No.81473554)

Allergic diseases and intestinal flora imbalance for allergic constitution research*

YANG Fei, WANG Ji, WANG Qi#   

  1. Center for Studies in TCM Constitution and Reproductive Science, Beijing University of Chinese Medicine, Beijing 100029
  • Received:2015-02-28 Online:2015-08-30 Published:2015-08-30

摘要: 研究发现过敏性疾病与肠道菌群失调密切相关,其具体机制未明,西医学认为可能与树突状细胞等免疫细胞导致的肠道通透性增高、肠道屏障破坏相关。根据中医理论,可以认为与“肺脏受邪,传于大肠”,“脾脏受邪,营养受限,微环境骚动”和“肝脏受邪,风气内动,微环境骚动”3个原因相关,根本原因在于“邪气凑之,正气必虚”。结合中医体质学的4个基本原理“生命过程论”“形神构成论”“环境制约论”“禀赋遗传论”探讨肠道菌群研究给中医过敏体质研究带来的启示。

关键词: 过敏性疾病, 食物过敏, 肠道菌群, 过敏体质, 启示

Abstract: Studies have shown that intestinal flora imbalance is closely related with allergic diseases, yet its specific mechanism remains unclear. Modern medicine considers that it may be associated with increased intestinal permeability and intestinal barrier disruption caused by dendritic cells and other immune cells. Traditional Chinese Medicine identifies three possible approaches, which are “Lungs invaded by evil passing to the large intestine”, “Spleen invaded by evil leading to restricted nutrition and disturbed microenvironment” and “Liver invaded by evil leading to stirred-up wind and disturbed microenvironment”. The root cause is that “Pathogenic factor invades when Zheng Qi is deficient”. This paper explores what intestinal flora research can bring to the allergic constitution study by combining the four fundamental theories “Life course theory”, “Composition of form and spirit”, “Environmental constraint theory”, and “Theory of innate endowment”.

Key words: allergic diseases, food allergies, intestinal flora, allergic constitution, implications

中图分类号: 

  • R2-031