主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2015, Vol. 38 ›› Issue (8): 573-576.doi: 10.3969/j.issn.1006-2157.2015.08.015

• 临床研究 • 上一篇    

加味当归补血汤调节IgA肾病肾虚血瘀证患者细胞因子的临床研究*

魏明刚1, 熊佩华1#, 孙伟2, 何伟明2, 张玲2, 费梅1   

  1. 1 苏州大学附属第一医院中西医结合科 江苏 215006;
    2 江苏省中医院肾科
  • 收稿日期:2014-08-05 出版日期:2015-08-30 发布日期:2015-08-30
  • 通讯作者: 熊佩华,女,主任医师,E-mail:weimg@sina.com
  • 作者简介:魏明刚,男,博士,副教授
  • 基金资助:
    国家自然科学基金面上项目(No.81273723,No.81473633),江苏高校优势学科建设工程项目,江苏省第二批老中医药专家学术经验继承工作项目

A clinical study on the effects of supplemented Danggui Buxue Decoction on cytokines in IgA glomerulonephritic patients of kidney deficiency and blood stasis pattern*

WEI Ming-gang1, XIONG Pei-hua1#, SUN Wei2, HE Wei-ming2, ZHANG Ling1, FEI Mei1   

  1. 1 The First Affiliated Hospital, Soochow University, Jiangsu 215006;
    2 Nephrology Department, Jiangsu Provincial Hospital of Traditional Chinese Medicine
  • Received:2014-08-05 Online:2015-08-30 Published:2015-08-30

摘要: 目的 研究加味当归补血汤对IgA肾病患者的抑制细胞因子聚集及延缓肾脏纤维化的保护作用。方法 将经过肾活检证实的IgA肾病患者进行随机分组治疗, 对照组仅使用基础治疗,治疗组在基础治疗的基础上加用加味当归补血汤。在治疗终点应用统计学方法分析2组患者血、尿细胞因子及纤维化相关指标,并进行组间疗效差异的比较。结果 治疗组和对照组均可减少24 h尿蛋白水平,治疗组由治疗前的(5.78±1.10)g下降至(1.25±0.67)g,而对照组由(5.25±1.21)g下降至(2.09±0.89)g。同时具有调节患者细胞因子和纤维化相关指标如单核细胞趋化蛋白-1 (MCP-1)、巨噬细胞移动抑制因子(MIF)、转化生长因子-β1(TGF-β1)、透明质酸酶(HA)、层粘连蛋白(LN)、胶原Ⅳ(Col-Ⅳ)、Ⅲ型前胶原N端肽P(PⅢNP)等的作用疗效显著,治疗前后自身对照改善均具有统计学意义(P<0.05)。2组治疗后以上数据的组间比较,除尿液LN外组间比较均有统计学意义,分析其在IgA肾病肾脏纤维化的意义表明治疗组的疗效优于对照组。结论 中药和西药治疗均对IgA肾病具有较好的抑制细胞因子聚集及延缓肾脏纤维化的保护作用,配合中药加味当归补血汤治疗可以明显提高临床疗效。

关键词: IgA肾病, 加味当归补血汤, 细胞因子, 纤维化相关指标, 临床研究

Abstract: Objective To investigate the effects of supplemented Danggui Buxue Tang (Chinese angelica blood-tonifying decoction) on inhibition of cytokine congregation and kidney cirrhosis in patients with IgA glomerulonephritis. Methods Histopathologically confirmed IgA grlomerulonephritic patients were randomly divided into two groups. Both groups received routine treatment while treatment group was given an extra supplemented Danggui Buxue Tang. Outcome measures were urine and blood cytokines and fibrosis related parameters to compare the differences between groups. Results 24h urine protein level was both reduced in treatment group (from 5.78±1.10 g to 1.25±0.67 g) and control group (from 5.25±1.21 g to 2.09±0.89 g). Cytokines and fibrosis related parameters including MCP-1, MIF, TGF-β1,HA, LN, Col-IV, and PIIINP were all significantly improved after intervention in both groups respectively (P<0.05). The difference between two groups was significant in all factors except LN. Conclusion Combined treatment of with conventional and Chinese medicine is effective for IgA glomerulonephritis in terms of inhibiting cytokine aggregation and delay kidney cirrhosis. Adding supplemented Danggui Buxue Tang according to TCM pattern identification seems to improve effectiveness significantly.

Key words: IgA nephropathy, Danggui Buxue Decoction, cytokines, renal fibrosis parameters, clinical study

中图分类号: 

  • R269.23