主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2016, Vol. 39 ›› Issue (2): 144-150.doi: 10.3969/j.issn.1006-2157.2016.02.012

• 临床研究 • 上一篇    下一篇

中医药降低早期糖尿病肾病患者蛋白尿水平疗效的Meta分析*

代晓颖1, 张燕1, 易静1#, 唐丽灵2, 何丽芳2   

  1. 1 重庆医科大学公共卫生与管理学院 医学与社会发展研究中心 健康领域社会风险预测治理协同创新中心 重庆 400016;
    2 重庆市卫生和计划生育委员会
  • 收稿日期:2015-08-22 出版日期:2016-02-28 发布日期:2016-02-28
  • 通讯作者: 易静,女,教授,硕士生导师,E-mail:yijinga@sina.com
  • 作者简介:代晓颖,女,在读硕士生
  • 基金资助:
    *世界卫生组织(WHO)“在初级卫生保健层面促进重庆市中医药服务研究”(No.WPCHN1408195)

Effects of Chinese medicine on proteinuria in patients with early diabetic nephropathy: a meta-analysis*

DAI Xiaoying1, ZHANG Yan1, YI Jing1#, TANG LI Ling2, HE Lifang2   

  1. 1 School of Public Health and Management, Chongqing Medical University, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health,Chongqing 400016;
    2 Health and Family Planning Commission of Chongqing
  • Received:2015-08-22 Online:2016-02-28 Published:2016-02-28

摘要: 目的 运用Meta分析法评价中医药降低早期糖尿病肾病患者蛋白尿水平的疗效及安全性。方法 计算机检索Medline、PubMed、Cochrane图书馆、中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)、中国知识资源总库(CNKI)中有关中医治疗早期糖尿病肾病的随机对照试验。依据修改后Jadad量表对纳入文献评分并采用Rev. Man 5.3软件进行Meta分析。结果 共纳入27个随机对照试验,涉及1 824名早期糖尿病肾病患者。与单纯使用血管紧张素转化酶抑制剂及血管紧张素Ⅱ受体拮抗剂(ACEI/ARB)的对照组相比,无论治疗组是否使用ACEI/ARB均可以有效降低尿微量白蛋白排泄率(UAER)水平和尿微量白蛋白/肌酐比,减少24 h尿蛋白定量,且无严重不良反应。结论 中药治疗早期糖尿肾病是安全和有效的。

关键词: 早期糖尿病肾病, 中医药, Meta分析, 血管紧张素转化酶抑制剂, 血管紧张素Ⅱ受体拮抗剂, 随机对照试验

Abstract: Objective To evaluate the effects of Traditional Chinese Medicine (TCM) on proteinuria in patients with early diabetic nephropathy (DN) by using meta-analysis. Methods All publications of randomized controlled trials (RCTs) studying traditional Chinese medicine in the treatment of early diabetic nephropathy were searched and identified from Medline, PubMed, Cochrane Library, CBM, VIP and CNKI. The quality of included studies were evaluated by using revised Jadad scale. Rev. Man 5.3 software was used for meta-analysis. Results A total of 27 RCTs involving 1 824 patients with early DN were included. Meta-analysis Results showed that TCM treatment group could reduce the level of urine albumin excretion rate (UAER) and 24h urine albumin level with or without using angiotensin converting enzyme inhibitor and angiotensin receptor blocker (ACEI/ARB), when compared to control group using ACEI/ARB only. No serious adverse reactions were observed in TCM treatment groups.Conclusion It was proved that the efficiency and safety of traditional Chinese medicine on proteinuria in patients with early diabetic nephropathy.

Key words: early diabetic nephropathy, traditional Chinese medicine, meta-analysis, ACEI, ARB, randomized controlled trials

中图分类号: 

  • R255.4