主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2016, Vol. 39 ›› Issue (9): 779-782.doi: 10.3969/j.issn.1006-2157.2016.09.016

• 临床研究 • 上一篇    下一篇

益气养阴消癥通络中药治疗IV期糖尿病肾病的临床研究

郭倩1, 陈志强2#, , 方敬1, , 白璐1, , 王月华3, , 郭登洲2, 王元松4, 周潮5, , 张江华1   

  1. 1 河北医科大学 河北 050017;
    2 河北省中医院;
    3 河北医科大学第三医院;
    4 河北省沧州中西医结合医院;
    5 河北省秦皇岛市中医院
  • 收稿日期:2016-04-12 出版日期:2016-09-30 发布日期:2016-09-30
  • 通讯作者: 陈志强,男,博士,教授,主任医师,博士生导师,研究方向:中西医结合治疗肾脏病,E-mail:chenzhqiang2011@163.com
  • 作者简介:郭倩,女,在读博士生
  • 基金资助:
    河北省科技支撑计划资助项目(No.09276101D-27)

Clinical efficacy of Yiqi Yangyin xiaozheng Tongluo Fang on patients with stage IV diabetic nephropathy*

GUO Qian1, CHEN Zhiqiang2#, FANG Jing1, BAI Lu1,WANG Yuehua3, GUO Dengzhou2, WANG Yuansong4, ZHOU Chao5, ZHANG Jianghua1   

  1. 1 Hebei Medical University, Hebei 050017;
    2 Hebei Traditional Chinese Medicine Hospital;
    3 The Third Hospital of Hebei Medical University;
    4 Hebei Province Cangzhou Hospital Integrated Traditional and Western Medicine;
    5 Hebei Province Qinhuangdao Traditional Chinese Medicine Hospital
  • Received:2016-04-12 Online:2016-09-30 Published:2016-09-30

摘要: 目的 探讨益气养阴消癥通络中药对IV期糖尿病肾病的治疗作用。方法 将符合纳入标准的160例IV期糖尿病肾病患者随机分为中药组81例和对照组79例,在基础治疗相同的情况下,中药组加益气养阴消癥通络中药治疗,对照组加厄贝沙坦治疗,总观察期为6个月。治疗前后分别观察2组患者终点事件发生率,症状改善情况,并检测尿微量白蛋白排泄率(mAlb)、24 h尿蛋白定量(U-pro/24 h)、血肌酐(Scr)、尿素氮(BUN)、空腹血糖(FPG)、糖化血红蛋白(HbAlc)、胆固醇(TC)、甘油三酯(TG)等指标。结果 中药组在随访过程中未出现进展至V期糖尿病肾病患者,对照组有2例治疗后血肌酐>133 μmol/L,但2组比较差异无统计学意义(P>0.05)。中药组患者乏力、口干、腰痛、水肿症状缓解有效率显著高于对照组(P<0.01)。与治疗前相比,2组mAlb、U-pro/24 h均明显降低(P<0.01)。与对照组治疗后相比,中药组治疗后mAlb、U-pro/24 h降低更为显著(P<0.05),并能降低甘油三酯水平(P<0.05)。结论 益气养阴消癥通络中药对IV期糖尿病肾病蛋白尿具有确切的治疗作用,并能降低甘油三酯水平,纠正脂代谢紊乱,且能改善糖尿病肾病患者症状,提高患者生存质量。

关键词: 益气养阴消癥通络中药, 糖尿病肾病, 临床研究, 厄贝沙坦

Abstract: Objective To investigate the clinical efficacy of Yiqi Yangyin xiaozheng Tongluo Fang (YYXTF), a Chinese medicine compounds formulated by the principle of replenishing qi, nourishing yin, eliminating abdominal masses, and freeing the collateral vessels, on patients with stage IV diabetic nephropathy (DN). Methods A total of 160 patients with stage IV diabetic nephropathy according to inclusion criteria were randomly divided into traditional Chinese medicine group (TCM group, n=81) and control group (n=79). In addition to general treatment, patients in TCM group took orally YYHXF and those in control group took irbesartan for consecutive six months. The incidence of end point events, improvement of clinical symptoms and urine micro-albumin excretion rate (mAlb), 24 hours urine total protein (U-pro/24 h), serum creatinine (Scr), blood urea nitrogen (BUN), fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlc), total cholesterol (TC) and triglycerides (TG) were recorded before and after treatment. Results During the follow-up period, compared with control group whose two patients with Scr >133 μmol/L, TCM group without patients progressing to stage V showed no statistical significance (P>0.05). Efficacy rate of relieving symptoms of hypodynamia, mouth dryness, back pain, edema in TCM group were significantly higher than that of control group (P<0.01). Intragroup comparison showed that mAlb and U-pro/24 h decreased after treatment (P<0.01). After treatment, mAlb and U-pro/24 h of TCM group were significantly lower than that of control group (P<0.05), and the level of TG of TCM group also decreased(P<0.05) . Conclusion Yiqi Yangyin Huayu Tongluo Fang showed definite therapeutic effect on stage IV diabetic nephropathy proteinuria. It could reduce TG levels and protected against dyslipidemia. In addition, it relieved the symptoms and improved the quality of patients’ life.

Key words: Yiqi Yangyin Xiaozheng Tongluo Fang, diabetic nephropathy, clinical trial, irbesartan

中图分类号: 

  • R225.4