主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2016, Vol. 39 ›› Issue (11): 920-925.doi: 10.3969/j.issn.1006-2157.2016.11.007

• 科技之窗 • 上一篇    下一篇

汉代以来著名医家治疗眩晕方剂用药规律的数据挖掘研究

刘旭东1,2,何庆勇1#,吴海芳1,2,钟小雪1,2   

  1. 1 中国中医科学院广安门医院 北京 100053;
    2 北京中医药大学
  • 收稿日期:2016-01-07 出版日期:2016-11-30 发布日期:2016-11-30
  • 通讯作者: 何庆勇,男,博士,副主任医师,副教授,硕士生导师,E-mail:heqingyongg@163.com
  • 作者简介:刘旭东,男,在读硕士生
  • 基金资助:
    国家自然科学基金资助项目(No.81202803),中央公益性科研院所基本科研业务费专项资金资助项目(No.ZZ0908023)

Ancient TCM doctors’ views on treatment of vertigo since Han Dynasty:a data mining research

LIU Xudong1,2 ,HE Qingyong1#, WU Haifang1,2 ,ZHONG Xiaoxue1,2   

  1. 1 Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053;
    2 Beijing University of Chinese Medicine
  • Received:2016-01-07 Online:2016-11-30 Published:2016-11-30

摘要: 目的 通过对汉代以来15位著名医家治疗眩晕方剂用药规律的数据挖掘研究,以期对临床治疗眩晕提供参考,并为研发治疗眩晕的中药新药提供依据。方法 收集整理汉代以来15位著名医家对眩晕的论述及医案共128条(方剂),输入“中医传承辅助系统(V2.5)”,采用改进的互信息法、关联规则、复杂系统熵聚类、无监督的熵层次聚类,对眩晕数据库中的证候统计、药对、角药、药物关联规则、核心药物组合演变与提取、新方发现进行研究。结果 眩晕证候最多的是肝阳上亢证(30次,23.4%);最常见单药是茯苓(49次,38.3%);其中最常用的对药是炙甘草-白术(29次,22.7%);最常用的角药是炙甘草-白术-茯苓(17次,占13.3%);关联度高的药物组合有白术+当归→炙甘草(置信度为0.937 5)。得到22组3味药的核心组合,核心药物为:人参、白术、炙甘草、陈皮、茯苓、当归;得到治疗眩晕的11个新候选处方。结论 提示今后研发治疗眩晕中药新药时优先以肝阳上亢证为适应证;单药、对药、角药优先考虑:茯苓、炙甘草、白术;配伍规律优先考虑:白术、当归配伍炙甘草,陈皮、白术配伍人参等;核心方剂优先考虑:茯苓-茯神-炙甘草,桑叶-白术-菊花等;新候选方优先考虑:茯苓、茯神、炙甘草、陈皮,桑叶、菊花、白术、人参等。

关键词: 眩晕, 关联规则, 数据挖掘, 学术思想, 新药研究

Abstract: Objective To study 15 famous ancient TCM docotors’ prescribing herbal medicines for treatment of vertigo from Han Dynasty and the following periods, so as to provide basis for clinical treatment on vertigo as well as for researching and developing new medicines for treating vertigo. Methods A total of 128 traditional Chinese medicine prescriptions were collected and input into TCM Inheritance Auxiliary Platform Version 2.5. Using the method of improved mutual information entropy clustering, association rules, complex systems entropy clustering and unsupervised entropy hierarchical clustering, the pattern types, pairs of drugs ( two Chinese medicines used together), triangle drugs (three Chinese medicines used together) , association rules of drugs, evolution and extraction of combination of the core drugs, and prescriptions newfound were analyzed. Results The leading pattern of vertigo was hyperactivity of liver yang (frequency:30; rate:23.4%. Same below). The most commonly used herbal medicine was Fuling (49, 38.3%), and the most common pair of drugs was Zhigancao-Baizhu (29,22.7%), the most common triangle drugs was Zhigancao-Baizhu-Fuling (17,13.3%). The drugs combination with high correlation was Baizhu-Danggui→Zhigancao, with support of 10% and confidence of 0.937 5. Altogether 22 sets of triangle drugs were extracted, in which the core drugs were Renshen, Baizhu, Zhigancao, Chenpi, Fuling, Danggui. And 11 new prescriptions were available. Conclusion For research and development of new drugs on vertigo, we should focus on the pattern of hyperactivity of liver yang; prior compatibility rules are Baizhu, Danggui with Zhigancao and Chenpi, Baizhu with Renshen and Zhigancao, Renshen with Baizhu; when formulate a new prescrption, Fuling, Fushen, Zhigancao, Chenpi, Sangye, Juhua, Baizhu and Renshen deserve the priority.

Key words: vertigo, association rules, data mining, academic thought, new drug research

中图分类号: 

  • R255.3