主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2017, Vol. 40 ›› Issue (1): 70-76.doi: 10.3969/j.issn.1006-2157.2017.01.014

• 临床研究 • 上一篇    下一篇

复健片促进皮质脊髓束重塑的临床观察*

李鑫1,2,刘伟3#,秦玲3   

  1. 1 山东中医药大学中医学院 山东 250014;
    2 山东中医药大学附属医院脑病科;
    3 山东中医药大学第一临床医学院
  • 收稿日期:2015-09-06 出版日期:2017-01-30 发布日期:2017-01-30
  • 通讯作者: 刘伟,男,副教授,主要研究方向:中医药治疗神经系统疾病的研究,E-mail:lwsdzyydx@163.com
  • 作者简介:李鑫,女,在读博士生,主治医师
  • 基金资助:
    *国家自然科学基金项目(No.81273701)

Clinical observation of Fujian Tablet on promoting the corticospinal tract remodeling of patients with cerebral ischemic stroke*

LI Xin1,2, LIU Wei3#, QIN Ling3   

  1. 1 Shandong University of Chinese Medicine, Shandong 250014;
    2 Department of Encephalopathy, Affiliated Hospital of Shandong University of Chinese Medicine;
    3 First Clinical Medical Hospital, Shandong University of Chinese Medicine
  • Received:2015-09-06 Online:2017-01-30 Published:2017-01-30

摘要: 目的 采用磁共振弥散张量成像技术(DTI),无创观测复健片对缺血性脑卒中颈髓皮质脊髓束重塑的修复作用,并评估其对运动功能恢复的重要意义。方法 收集符合纳入标准的60例病例,随机分为治疗组和对照组,各30例。两组患者都给予常规西药治疗,治疗组患者同时给予中药复健片。在治疗前和治疗后,均对60例患者各进行1次ADL评分、CSS评分及颈髓的DTI检测,并分析两组患者DTI数据与CSS评分之间的相关性。结果 研究显示,与对照组比较,治疗组患者的日常生活能力、临床神经功能缺损恢复程度改善更明显 (P<0.01),治疗组患者治疗后的DTI数据明显低于治疗前的DTI数据 (P<0.01),且较对照组改善明显(P<0.01),两组患者的CSS评分与△FA值均存在显著的正相关性(P<0.01),且治疗组的CSS评分与△FA值的相关系数比对照组高。两种治疗方案对血液常规、肝功能、肾功能均未产生不良影响。结论 复健片能够促进皮质脊髓束修复,明显改善患者运动功能且不增加服药风险。

关键词: 复健片, 缺血性脑卒中, 磁共振弥散张量成像技术, 皮质脊髓束, 运动功能

Abstract: Objective Based on diffusion tensor imaging (DTI) technology, to noninvasively evaluate the remodeling effect of Fujian Tablet on corticospinal tract of patients with cerebral ischemic stroke (CIS) by taking activities of daily living(ADL)score and Chinese stroke scale (CSS) score as the indicators, and to assess the significance of recovery of patients’motor function. Methods 60 cases according to the inclusive criteria were randomly divided into control group and treatment group (each n=30). All patients took conventional western medicine, in addition, those in treatment group took orally Fujian Tablet for 60 days. Before and after treatment, CSS score and ADL score were recorded, and the corticospinal tract was detected by using DTI. Then the correlation between data from DTI and CSS score were analyzed. Results Improvement of patients’ activities in daily life, recovery of neurological damage in treatment group were superior to those in the control group (P<0.01). And after treatment, DTI data in the treatment group was much less than that before (P<0.01), the improvement showed significance compared with the control group (P<0.01). The positive correlation of CSS score and △FA was proved in both groups(P<0.01), with the correlation coefficient of the treatment group higher. Furthermore, no adverse effects were found in indicators of the routine blood test, liver function and kidney function. Conclusion Fujian Tablets could promote the remodeling of corticospinal tract and improve the motor function of CIS patients without increasing the risk of taking more drugs.

Key words: Fujian Tablets, cerebral ischemic stroke, diffusion tensor imaging, corticospinal tract, motor function

中图分类号: 

  • R255.2