主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2017, Vol. 40 ›› Issue (1): 77-82.doi: 10.3969/j.issn.1006-2157.2017.01.015

• 临床研究 • 上一篇    下一篇

化痰调经方联合达英-35治疗多囊卵巢综合征痰湿阻滞证的临床研究*

王萍1,邵渝1,林辉2#,陈华盈3,黄群4   

  1. 1 湖南中医药大学 湖南 410208;
    2 湖南中医药高等专科学校;
    3 湖南省长沙市中医医院;
    4 湖南中医药高等专科学校附属第一医院
  • 收稿日期:2016-09-05 出版日期:2017-01-30 发布日期:2017-01-30
  • 通讯作者: 林辉,男,博士,教授,主要研究方向:中西医结合慢病防治,E-mail:274239573@qq.com
  • 作者简介:王萍,女,教授,主任医师,硕士生导师
  • 基金资助:
    *湖南省中医药科研计划项目(No.2015122)

Clinical study on Huatan Tiaojing Fang combined with Diane-35 on treatment of polycystic ovary syndrome patients with phlegm-dampness obstruction pattern*

WANG Ping 1, SHAO Yu1, LIN Hui2#, CHEN Huaying3, HUANG Qun4   

  1. 1 Hunan University of Traditional Chinese Medicine, Hunan 410208;
    2 Hunan Traditional Chinese Medical College;
    3 Changsha Hospital of Traditional Chinese Medicine, Hunan Province;
    4 First Affiliated Hospital, Hunan Traditional Chinese Medical College
  • Received:2016-09-05 Online:2017-01-30 Published:2017-01-30

摘要: 目的 探讨化痰调经方联合达英-35治疗多囊卵巢综合征(PCOS)痰湿阻滞证的疗效与机制。方法 60例 PCOS患者随机分为治疗组与对照组,每组30例,对照组予达英-35口服,治疗组在对照组治疗基础上予化痰调经方口服,共治疗3个月,疗程结束后观察临床疗效、血清性激素水平、卵巢体积及卵巢窦卵泡数(AFC)等指标。结果 治疗组总有效率为96.7%,对照组90.0%,两组总体疗效相当(P>0.05);治疗组在治疗后与停药3月后单项症状积分方面优于对照组(P<0.05);治疗后患者血清雌二醇(Estradiol,E2)、睾酮(Testosterone,T)、血清促卵泡生成激素(Follicle Stimulating Hormone,FSH)水平和卵巢体积变化两组比较无显著性差异(P>0.05),治疗组在调节血清黄体生成素(Luteinizing Hormone,LH)、LH/FSH水平及减少基础AFC方面优于对照组(P<0.05)。结论 化痰调经方联合达英-35治疗PCOS痰湿阻滞证疗效确切,在改善痰湿症状方面优于单用达英-35,其机制可能与调节血清LH、LH/FSH有关。

关键词: 化痰调经方, 达英-35, 多囊卵巢综合征, 痰湿阻滞证, 临床研究

Abstract: Objective To observe the effect and mechanism of Huatan Tiaojing Fang, a Chinese medicine compound formulated by the principle of resolving phlegm and regulating menstruation, combined with Diane-35 on polycystic ovary syndrome (PCOS) patients with phlegm-dampness obstruction pattern. Methods A total 60 patients were randomly divided into the treatment group and the control group (each n=30). The patients of the control group took orally Diane-35, and those of the treatment group took orally Diane-35 with Huatan Tiaojing Fang for consecutive three months. Before and after treatment, TCM symptom total score and individual symptoms integral, menstruation efficacy, serum sex hormone levels,ovarian volume and basal antral follicle count (AFC) were detected and analyzed. Results The total effective rates were equal, 96.7% in the treatment group and of 90.0% in the control group (P>0.05). The individual symptoms integral of the treatment group was superior to those of the control group at the end of three months and three months of withdrawal (P<0.05). After treatment, despite there was no significant difference in serum estradiol (E2), testosterone (T), follicle stimulating hormone (FSH) and ovarian volume (P>0.05), the regulation of serum luterinizing hormone (LH) and LH/FSH, reduction of basal AFC of the treatment group were superior to those of the control group (P< 0.05). Conclusion The clinical effectiveness of Huatan Tiaojing Fang combined with Diane-35 on treatment of PCOS with phlegm-dampness obstruction pattern has been proved, superior to the effectiveness of Diane-35. The potential mechanism is related to regulating serum LH and LH/FSH.

Key words: Huatan Tiaojing Fang, Diane-35, polycystic ovarian syndrome, phlegm-dampness obstruction pattern, clinical study

中图分类号: 

  • R271.175