主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2017, Vol. 40 ›› Issue (1): 83-88.doi: 10.3969/j.issn.1006-2157.2017.01.016

• 临床研究 • 上一篇    

基于现代医案探讨小青龙汤的应用规律*

杨淑慧,丁吉善,郅琳   

  1. 南阳理工学院 河南 473004
  • 收稿日期:2016-08-29 出版日期:2017-01-30 发布日期:2017-01-30
  • 作者简介:杨淑慧,女,硕士,讲师
  • 基金资助:
    *国家中医药管理局中医药科技专项(No.2009ZX07-02),河南省科技厅科技攻关项目(No.152102310225)

Application rules of Xiaoqinglong Decoction based on the modern medical records*

YANG Shuhui, DING Jishan, ZHI Lin   

  1. Nanyang Institute of Science and Technology, Henan 473004
  • Received:2016-08-29 Online:2017-01-30 Published:2017-01-30

摘要: 目的 探讨小青龙汤在现代临床中的应用规律,为古方今用提供思路和方法。方法 从中国知网(CNKI)期刊数据库中筛选出方名中明确提到小青龙汤,且临床疗效明显、临床资料完整的论文599篇,从中获得786例医案,分别录入Excel表格。对记录中的病名、症状、药物进行规范,然后进行统计分析。利用SPSS 20.0统计软件对病名、症状、药物进行频数分析,并根据黄金分割法筛选出小青龙汤证的主症;对频次≥20的高频症状进行聚类分析,包括层次聚类中的指标聚类、Ward法、Pearson相关性分析。结果 786例医案共有西医疾病68种,中医疾病45种;频次≥20的症状48个、药物46味、舌质8种、舌苔7种、脉象10种,筛选出小青龙汤证的主症6个;有意义的聚类组17组。结论 小青龙汤在现代临床中的应用范围以支气管炎、支气管哮喘等肺系疾病为主,亦可治疗肺病及心所致肺心病、心力衰竭等或由痰饮导致的其他病证;小青龙汤的主要应用指征是咳嗽、气喘、咯痰、痰白、舌淡、苔白,主要兼症有阳虚证、瘀血证、表寒证、里热证;小青龙汤证的基本病机是痰饮阻肺,病位在肺,可向脾肾阳虚、心脉瘀阻、里热伤阴等方向发展。

关键词: 小青龙汤, 现代医案, 应用规律, 数据挖掘

Abstract: Objective To explore the application rules of Xiaoqinglong Decoction in modern clinical practice, in order to provide a new idea and method for ancient Chinese herbal medicine compound to serve the present days. Methods Retrieving CNKI database, eligible 599 articles were selected through the keyword of “小青龙汤”, with remarkable effect and complete clinical information. Altogether 786 cases from the articles were input Excel table. The disease names, symptoms and the herbal medicineswere standardized, and their frequency were analyzed. Then the primary symptoms of Xiaoqinglong Decoction Syndrome were screened by using Golden Section Method, and the symptoms with frequency of 20 or above were performed cluster analysis including hierarchical clustering, Ward method and Pearson dependency. Results There are 68 western disease names and 45 TCM disease names, and 48 symptoms, 46 herbal medicines, 8 tongue texture, 7 tongue coating and 10 pulse manifestion with frequency of 20 or above. As the consequence, six primary symptoms and 17 significant cluster sets were screened. Conclusion Xiaoqinglong Decoction was undoubtedly used for pulmonary diseases including bronchitis, bronchial asthma, as well as cardiac diseases including cor pulmonale, heart failure arisen from pulmonary diseases, and other diseases due to phlegm and fluid retention. The indications of Xiaoqinglong Decoction were listed as cough, asthma, expectoration, white sputum, pale tongue and white tongue coating, with the accompanied symptoms of yang-deficiency syndrome, blood stasis syndrome, exogenous cold syndrome and interior heat syndrome. The basic pathogenesis of Xiaoqinglong Decoction Syndrome was referred as phlegm and fluid retention accumulated in the lung with the disease location of lung, which could aggravate to yang-deficiency in spleen and kidney, blood stasis in heart vessels or interior heat consuming yin.

Key words: Xiaoqinglong Decoction, modern medical records, application rules, data mining

中图分类号: 

  • R289.5