主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2017, Vol. 40 ›› Issue (8): 693-698.doi: 10.3969/j.issn.1006-2157.2017.08.012

• 临床研究 • 上一篇    下一篇

801例肝炎肝硬化患者病性类证候要素与常见脉象的相关性分析

赵丽红1, 王天芳1#, 薛晓琳1, 吴秀艳1, 李宁1, 李永纲2, 李昕3, 陈盛铎4孙凤霞5, 李秀惠6, 毛德文7, 刘燕玲8, 张厂9, 刘汶10, 张秋云11   

  1. 1 北京中医药大学 北京 100029;
    2 解放军302医院;
    3 北京中医药大学东直门医院;
    4 湖北省中医院;
    5 首都医科大学附属北京地坛医院;
    6 首都医科大学附属北京佑安医院;
    7 广西中医药大学第一附属医院;
    8 中国中医科学院西苑医院;
    9 北京中医药大学东方医院;
    10 首都医科大学附属北京中医医院;
    11 首都医科大学中医药学院
  • 收稿日期:2017-03-01 出版日期:2017-08-10 发布日期:2017-08-10
  • 通讯作者: 王天芳,女,博士,教授,博士生导师,研究方向:症、证的规范化、标准化研究,E-mail:tianfangwang2000@163.com
  • 作者简介:赵丽红,女,博士,助理研究员
  • 基金资助:
    国家重点基础研究发展计划(973计划)项目(No.2011CB505105),国家自然科学基金项目(No. 81473598),北京中医药大学新奥奖励基金项目(No.1000062720037/001)

Correlation between pattern elements of disease nature and common pulse manifestation in 801 patients with viral hepatitis cirrhosis*

ZHAO Lihong1,WANG Tianfang1#,XUE Xiaolin1,WU Xiuyan1,LI Ning1,LI Yonggang2,LI Xin3,CHEN Shengduo4,SUN Fengxia5,LI Xiuhui6,MAO Dewen7,LIU Yanling8,ZHANGChang9,LIU Wen10,ZHANG Qiuyun11   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Chinese PLA 302 Hospital, Beijing 100039, China;
    3 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
    4 Chinese Medicine Hospital of Hubei Province, Hubei 430061, China;
    5 Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China;
    6 Beijing You’an Hospital, Capital Medical University, Beijing 100069, China;
    7 First Affiliated Hospital of Guangxi College of Chinese Medicine, Guangxi 530023, China;
    8 Xiyuan Hospital, CACMS, Beijing 100091, China;
    9 Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078,China;
    10 Beijing Hospital of Traditional Chinese Medicine, Beijing 100010, China;
    11 School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
  • Received:2017-03-01 Online:2017-08-10 Published:2017-08-10
  • Supported by:
    National Program on Key Basic Research Project (973 Program)(No.2011CB505105), National Natural Science Foundation of China(No. 81473598)

摘要: 目的 基于病证结合分析肝炎肝硬化患者病性类证候要素与常见脉象的相关性,为丰富常见脉象的临床意义以及探讨其形成机理提供依据。方法 运用课题组统一制订的《肝炎肝硬化临床信息采集表》,进行全国多中心的横断面流行病学调查,收集肝炎肝硬化患者的中医症状、舌象、脉象(包括深浅、至数、宽细、长短、硬度、流利度等)信息,制订《肝炎肝硬化常见证候要素辨识标准》,依此判定患者的病性类证候要素类型;统计学方法采用频数、频率等描述性分析、卡方检验与简单相关分析的方法。结果 801例患者中,选取出现频率大于20%的作为常见脉象,其中弦脉602例(75.2%),细脉279例(34.8%),沉脉232例(29.0%),滑脉185例(23.1%)。弦脉与血瘀、气滞呈正相关关系,相关系数r分别为0.141、0.166(P<0.05);滑脉与阴虚、湿热呈正相关关系,相关系数r分别为0.093、0.131(P<0.05);沉脉与气虚、阳虚呈正相关关系,相关系数r分别为0.099、0.111(P<0.05);细脉与阴虚、气虚、阳虚、水停呈正相关关系,相关系数r分别为0.089、0.109、0.105、0.075(P<0.05)。结论 肝炎肝硬化患者病性类证候要素与常见脉象间存在一定的相关性。

关键词: 肝炎肝硬化, 脉象, 病性类证候要素

Abstract: Objective To enrich the clinical meanings of common pulse manifestations, and to explore mechanisms of those pulses by analyzing the correlation between pattern elements of disease nature and common pulse manifestations in patients with viral hepatitis or cirrhosis based on the combination of pattern and diseases. Methods A national multicenter cross-sectional epidemiological survey was conducted to collect TCM symptoms, tongue manifestations and pulse conditions(including depth, frequency, width, length, hardness, and frequency of pulse)of patients with viral hepatitis or cirrhosis. The survey questionnaire used the Information Collection form of Vital Hepatitis Cirrhosis drafted by the research group. Standard of Hepatitis Cirrhosis Pattern Elements Differentiation was made to identify patterns and pattern elements.Descriptive statistics such as frequency and rate, Chi-square test,and correlation analysis were used.Results Pulses of 801 patients were collected. Pulses with occurrence rate above 20% was defined as common pulse manifestations, in which wiry pulse accounted for 75.2% (n=602);thready pulse,29.0 % (n=279);deep pulse 29% (n=232); and slippery pulse, 23.1% (n=185). There was positive correlation between wiry pulse and blood stasis and qi stagnation (correlation coefficient was 0.141 and 0.166 respectively,P<0.05).There was positive correlation between slippery pulse and yin deficiency and damp heat (correlation coefficient were 0.093 and 0.131 respectively,P<0.05). There was positive correlation between deep pulse and qi deficiency and yang deficiency(correlation coefficient was 0.099 and 0.111 respectively, P<0.05). There was positive correlation between thready pulse pulse and yin deficiency,qi deficiency, yang deficiency and water retention(correlation coefficient was 0.089,0.109,0.105 and 0.075 respectively, P<0.05). Conclusion There is a certain correlation between pattern elements and common pulse manifestations in viral hepatitis cirrhosis patients.

Key words: viral hepatitis cirrhosis, pulse manifestation, pattern elements of disease nature

中图分类号: 

  • R575.2