主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2018, Vol. 41 ›› Issue (3): 253-258.doi: 10.3969/j.issn.1006-2157.2018.03.013

• 临床研究 • 上一篇    下一篇

含海洋中药的抗肿瘤方剂用药规律分析*

韦明婵, 林江#, 易劲苍, 童远明, 张荻娅, 邹天骏   

  1. 广西中医药大学基础医学院 广西 530200
  • 收稿日期:2017-04-25 出版日期:2018-03-30 发布日期:2018-03-30
  • 通讯作者: # 林江,女,博士,教授,博士生导师,研究方向:海洋药及方剂应用基础研究, E-mail:1713552545@qq.com
  • 作者简介:韦明婵,女,在读硕士生
  • 基金资助:
    *国家公共卫生专项子项目广西海洋药物资源普查(No.GXZYZYPC13-7-1),广西自然科学基金重点项目(No.2015GXNSFDA227002),广西科技基地和人才专项(No.桂科AD17195080),国家级海洋经济创新发展示范城市(北海市)产业链协同创新项目(No.Bhsfs002),广西中医药大学2016年硕士研究生科研创新项目(No.YJS201621)

Medication rules of anti-tumor formulas containing marine Chinese medicinals*

Wei Mingchan, Lin Jiang#, Yi Jincang, Tong Yuanming, Zhang Diya, Zou Tianjun   

  1. School of Basic Medical Sciences, Guangxi University of Chinese Medicine, Guangxi 530200, China
  • Received:2017-04-25 Online:2018-03-30 Published:2018-03-30
  • Supported by:
    *Marine Medicinals Resource Censor of Guangxi, National Public Health Program (No. GXZYZYPC13-7-1) , Key Project of Natural Science Foundation of Guangxi (No.2015GXNSFDA27002)

摘要: 目的 探讨含海洋中药的抗肿瘤方剂的组方用药规律。方法 在《海洋药物与效方》《中国海洋药物辞典》《中华海洋本草》等中医书籍及中国知网等数据库收集含海洋中药的抗肿瘤方剂,运用中医传承辅助平台软件V2.5建立数据库,进行数据挖掘。结果 筛选到含海洋中药的抗肿瘤方剂251首,涉及中药417味,其中海洋中药36味;药性以寒、平、温为主,药味以苦、辛、甘、咸居多,主要入肝、肺、胃、脾、心经。关联规则发现牡蛎-海藻-昆布为核心组合,临床主要与清热药、补虚药、化痰散结药、活血化瘀药配伍使用;熵聚类分析发现核心药物组合12个,分别为海藻-海蛤壳-昆布,皂角刺-穿山甲-僵蚕,木香-瓦楞子-蒲黄,蟾酥-雄黄-珍珠,黄柏-鱼脑石-冰片,海马-青皮-牵牛子,海藻-昆布-甘草,王不留行-穿山甲-牡蛎,蜂房-瓦楞子-全蝎,麝香-血竭-珍珠,黄柏-乳香-冰片,青皮-五灵脂-大腹皮。发现新处方6个:海藻-海蛤壳-昆布-甘草,皂角刺-穿山甲-僵蚕-王不留行-牡蛎,木香-瓦楞子-蒲黄-蜂房-全蝎,蟾酥-雄黄-珍珠-麝香-血竭,黄柏-鱼脑石-冰片-乳香,海马-青皮-牵牛子-五灵脂-大腹皮。含海洋中药的抗肿瘤方剂治疗肿瘤共47种,高频出现的依次为甲状腺肿瘤、肺癌、肝癌、子宫肌瘤、鼻咽癌、食管癌、胃癌、乳腺癌。结论 海洋中药在肿瘤治疗领域有规律可循,通过不同的配伍达到不同的治疗作用,其用药规律对于指导临床用药及新药开发具有重要的价值。

关键词: 肿瘤, 海洋中药, 方剂, 用药规律, 中医传承辅助平台

Abstract: Objective To investigate the rules of medication and combinations of anti-tumor formulas containing marine Chinese medicinals. Methods The anti-tumor formulas containing marine Chinese medicinal were collected from Marine Chinese Medicinal and Effective formulas, Dictionary of Chinese Marine Medicinals, Marine Chinese Materia Medica, and databases including CNKI. A database was established for data mining by using V2.5 software of TCM inheritance support system (TCMISS). Results There were totally 251 anti-tumor formulas containing marine Chinese medicinals involved 417 Chinese medicinal including 36 marine Chinese medicinals. The nature of medicinals in these formulas were mainly cold, neutral and warm, flavors of them were mainly bitterness, pungency, sweetness and saltiness, and they mainly entered into meridians of liver, lung, stomach, spleen and heart. The analysis of association rules showed that core combination was Muli (Oyster Shell, Concha Ostreae)-Haizao (Seaweed, Sargassum)-Kunbu (Kelp, Thallus Laminariae), which was commonly combined with medicinals with effects of clearing heart, tonifying, resolving phlegm, dissipating binds, activating blood and resolving stasis in clinical practice. Entropy clustering analysis showed that there were 12 combinations with core medicinals, and they were Haizao-Haigeqiao (Clam Shell, Goncha Meretricis seu Cyclinae)-Kunbu, Zaojiaoci (Chinese Honeylocust Spine, Spina Gleditsiae)-Chuanshanjia (Pangolin Scales, Squama Manitis)-Jiangcan (Batryticated Silkworm, Bombyx Batryticatus), Muxiang (Common Aucklandia Root, Radix Aucklandiae)-Walengzi (Ark Shell, Concha Arcae)-Puhuang (Cattail Pollen, Pollen Typhae), Chansu (Toad Venom, Venenum Bufonis)-Xionghuang (Realgar, Realgar)-Zhenzhu (Pearl, Pernulo), Huangbai (Amur Cork-Tree, Cortex Phellodendri)-Yunaoshi (Fish Otolith, Asteriscus Pseudosciaenae)-Bingpian (Bomeol, Bomeolum Syntheticum), Haima (Sea Horse, Hippocampus)-Qingpi (Green Tangerine Peel, Pericarpium Citri Reticulatae Viride)-Qianniuzi (Pharbitis Seed, Semen Pharbitidis), Haizao-Kunbu-Gancao (Liquorice Root, Radix Glycyrrhizae), Wangbuliuxing (Vaccaria Seed, Semen Vaccariae)-Chuanshanjia-Muli, Fengfang (Hornet Nest, Nidus Vespae)-Walengzi-Qianxie (Scorpion, Scorpio), Shexiang (Musk, Moschus)-Xuejie (Dragon’s Blood, Risina Draconis)-Zhenzhu, Huangbai (Amur Cork-Tree, Cortex Phellodendri)-Ruxiang (Frankincense, Olibanum)-Bingpian, and Qingpi-Wulingzhi (Trogopterus Dung, Faeces Trogopterorum)-Dafupi (Shell of Arecanut, Pericarpium Arecae). There were 6 new combinations, and they were Haizao-Haigeqiao-Kunbu-Gancao, Zaojiaoci-Chuanshanjia-Jiangcan-Wangbuliuxing-Muli, Muxiang-Walengzi-Puhuang-Fengfang-Qianxie, Chansu-Xionghuang-Zhenzhu-Shexiang-Xuejie, Huangbai-Yunaoshi-Bingpian-Ruxiang, and Haima-Qingpi-Qianniuzi-Wulingzhi-Dafupi. The high-frequency tumor diseases, totally 47, treated with anti-tumor formulas containing marine Chinese medicinals, were successively thyroid tumor, lung cancer, liver cancer, uterine fibroids, nasopharyngeal carcinoma, esophageal cancer, gastric cancer and mammary cancer. Conclusion There are rules to follow in treatment of tumors with marine Chinese medicinal. The different therapeutic effects can be achieved by different medicinal combinations, which has a very important value in guiding clinical medication and new medicinal development.

Key words: tumor, marine Chinese medicinals, formulas, medication rule, TCM inheritance support system

中图分类号: 

  • R282.77