主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2018, Vol. 41 ›› Issue (6): 523-528.doi: 10.3969/j.issn.1006-2157.2018.06.014

• 临床研究 • 上一篇    

苦碟子注射液对急性脑梗死患者血清神经递质的影响*

曾子修1, 刘雪梅2, 梁晓1, 陈宝鑫2, 刘晓汉1, 温彬宇2, 徐榛敏1, 方晓磊2, 张允岭3#   

  1. 1 北京中医药大学 北京 100029;
    2 北京中医药大学东方医院;
    3 中国中医科学院西苑医院
  • 收稿日期:2018-01-12 出版日期:2018-06-30 发布日期:2018-06-30
  • 通讯作者: 张允岭,男,博士,主任医师,博士生导师,研究方向:中医药防治脑血管病,E-mail:yunlingzhang2004@163.com
  • 作者简介:曾子修,女,在读硕士生
  • 基金资助:
    *国家国际科技合作专项项目(No.2015DFA31130),国家重点基础研究发展计划(973计划)项目(No.2012CB518406),国家自然科学基金项目(No.81774250)

Effects of Kudiezi injection on serum neurotransmitters in patients with acute cerebral infarction*

Zeng Zixiu1, Liu Xuemei2, Liang Xiao1, Chen Baoxin2, Liu Xiaohan1, Wen Binyu2, Xu Zhenmin1, Fang Xiaolei2, Zhang Yunling3#   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China;
    3 Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
  • Received:2018-01-12 Online:2018-06-30 Published:2018-06-30
  • Supported by:
    International S&T Cooperation Program of China (No.2015DFA31130), National Key Basic Research Program of China (973 Program)(No.2012CB518406), National Natural Science Foundation of China(No.81774250)

摘要: 目的 观察急性脑梗死患者入院后第1、3、5、14天血清中神经递质的含量变化,研究苦碟子注射液的治疗作用。方法 发病时间≤48 h的急性脑梗死患者,随机分为基础治疗组(20例),基础治疗+苦碟子注射液组(20例),共40例。采集患者入院后第1、3、5、14天血清,超高效液相四级杆飞行时间质谱法(UPLC-Q-TOF-MS)检测血清谷氨酸(Glu)、5-羟色胺(5-HT)浓度。结果 随着治疗时间的延长,苦碟子注射液可明显降低患者血清5-HT及Glu浓度,且与基础治疗组相对应时间点比较,苦碟子注射液组第3、14天血清5-HT浓度及第5、14天血清Glu浓度明显低于基础治疗组(P<0.05),且治疗14 d后,苦碟子注射液组较基础治疗组血清Glu浓度显著降低(P<0.05)。结论 苦碟子注射液可较早地降低急性脑梗死患者血清Glu、5-HT浓度。

关键词: 急性脑梗死, 苦碟子注射液, 谷氨酸, 5-羟色胺

Abstract: Objective To observe changes of serum neurotransmitters in patients with acute cerebral infarction on the 1st, 3rd, 5th and 14th days after admission, and to study the therapeutic effects of the Kudiezi(KDZ) injection. Methods Forty patients with acute cerebral infarction within 48 hours were recruited and randomly divided into routine treatment group (n=20), routine treatment+KDZ injection group (n=20). Patient serum samples were collected on the1st, 3rd, 5th, and 14thdays to measure concentration of glutamate (Glu) and 5-hydroxytryptamine (5-HT) by using UPLC-Q-TOF-MS. Results Kudiezi injection could significantly decrease the concentration of 5-HT and Glu over time. Concentrations of Glu at day 5 and 14 and 5-HT in KDZ treatment group at day 3 and 14 were significantly lower than those in the routine treatment group at the same time (P<0.05);and after 14 days of treatment, the concentration of Glu decreased significantly in the KDZ treatment group(P<0.05). Conclusion Kudiezi injection can significantly reduce the serum concentrations of Glu and 5-HT in acute cerebral infarction patientsat early time.

Key words: acute cerebral infarction, Kudiezi injection, glutamate, 5-hydroxytryptamine

中图分类号: 

  • R255.2