主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2018, Vol. 41 ›› Issue (7): 542-546.doi: 10.3969/j.issn.1006-2157.2018.07.003

• 理论研究 • 上一篇    下一篇

从“风毒入络”论中晚期肺癌远端转移病机*

何伟   

  1. 陕西中医药大学基础医学院 陕西 712046
  • 收稿日期:2018-01-29 出版日期:2018-07-30 发布日期:2018-07-30
  • 作者简介:何伟,男,博士,副教授
  • 基金资助:
    国家重点基础研究发展计划(973计划)资助项目(No.2013CB532002),陕西省中医药管理局科研课题 (No.15-SCJH011)

On pathogenesis of distal metastasis of moderate and advanced lung cancer based on theory of wind-toxin entering collaterals*

He Wei   

  1. School of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Shaanxi 712046, China
  • Received:2018-01-29 Online:2018-07-30 Published:2018-07-30
  • Supported by:
    National Key Basic Research Development Plan (973 Program, No. 2013CB532002), Project of Shaanxi Administration of Traditional Chinese Medicine (No.15-SCJH011)

摘要: 从病程、病情、病性、病势、病状来看,中晚期肺癌远端转移,符合风邪致病的善行数变,以及癌毒暴戾多变的特性,属于内风挟携癌毒,化生风毒所致。风毒指具有风邪及毒邪的病邪性质、症状表现或病机特点的一类致病因素,可分为外感风毒及内生风毒,外感风毒促进肺癌的发生,而内生风毒主要参与肺癌病机演化,为病势发展的转折点。风毒主要通过络脉及三焦为转移途径,冲逆流窜髓络,引起中晚期肺癌骨脑转移,其主要病机包括:肺气阴两虚,治节失调,欲酿风毒之势。肺百脉失和,瘀毒阻络化风,是肺癌风气内动的始动病机。肝体用失和,风毒冲逆脑窍髓络,是肺癌脑转移的核心病机。肾精亏虚,作强失司,风毒流窜骨腔髓络,是肺癌骨转移的主要病机。“风毒入络”作为中晚期肺癌远端转移的核心病机,决定着中晚期肺癌患者生活质量好坏及生存周期长短,而从“风毒”及“络病”论治中晚期肺癌,为确立有效辨治法则,筛选有效治疗药物,具有一定的病因病机学理论参考意义。

关键词: 风毒, 肺癌, 肿瘤转移, 病机

Abstract: The distal metastasis of moderate and advanced lung cancer, based on disease course, condition, nature, severity and morbidity, conforms to pathogenic wind’s features of rapid movement and swift changes and violent changeable characteristics of cancer toxin, which dues to internal wind carrying cancer toxin and transferring into wind toxin. Wind toxin is a pathogenic factor with disease-evil natures, symptomatic manifestations and pathogenesis characteristics of wind-evil and toxin. It can be classified into external wind toxin and internal wind toxin. The external wind toxin promotes the development of lung cancer, and internal wind toxin mainly takes part in the evolution of lung cancer pathogenesis, which is a turning point of lung cancer development. The wind toxin mainly takes collaterals and triple energizers as its route of metastasis and thrusts medullar collaterals, which causes bone and brain metastases of middle and advanced lung cancer. The principal pathogenesis is dual deficiency of lung qi and yin and disorders of governing management leading production of wind toxin. The initial pathogenesis of wind stirring inside of lung cancer is that hundred vessels become estranged, stasis toxin hinders collaterals and wind forms. The core pathogenesis of brain metastases of lung cancer is that liver body and function become unbalance, and wind toxin thrusts brain orifice and medullar collaterals. The principal pathogenesis of bone metastasis of lung cancer is that kidney essence is deficient, kidney’s functions of reproduction and growth are dysfunctional, and wind toxin flows bone cavity and medullar collaterals. Discussing the pathogenesis of bone and brain metastasis of lung cancer based on theory of wind-toxin entering collaterals has a higher clinical reference value for enriching the theoretical system of etiology and pathogenesis of TCM oncology, determining the visceral levels of tumor, confirming the key factors of tumor metastasis and improving the accuracy of tumor differentiation and treatment.

Key words: wind toxin, lung cancer, tumor metastasis, pathogenesis

中图分类号: 

  • R273.42