主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2018, Vol. 41 ›› Issue (10): 863-872.doi: 10.3969/j.issn.1006-2157.2018.10.013

• 临床研究 • 上一篇    下一篇

中医药治疗男性少弱精子症疗效的Meta分析*

李博怿1, 王琦1, 朱斌2, 杨培英1, 董阳1, 阎基1, 郑燕飞1#   

  1. 1 北京中医药大学中医学院 北京 100029;
    2 首都医科大学附属北京天坛医院
  • 收稿日期:2018-01-21 出版日期:2018-10-30 发布日期:2018-10-30
  • 通讯作者: 郑燕飞,男,博士,副研究员,研究方向:中医生殖医学,E-mail:yanfei_z@163.com
  • 作者简介:李博怿,男,在读硕士生
  • 基金资助:
    国家自然科学基金资助项目(No. 81503584)

Meta-analysis of effectiveness of traditional Chinese medicine in the treatment of oligospermia and asthenospermia*

Li Boyi1, Wang Qi1, Zhu Bin2, Yang Peiying1, Dong Yang1, Yan Ji1, Zheng Yanfei1#   

  1. 1 School of Traditional Chinese Medicine, Beijing University of Chinese Medicine,Beijing 100029,China;
    2 Beijing Tian Tan Hospital,Capital Medical University,Beijing 100050,China
  • Received:2018-01-21 Online:2018-10-30 Published:2018-10-30

摘要: 目的 运用Meta分析方法系统评价中医药治疗少弱精子症的疗效。方法 检索中国期刊全文数据库(CNKI)、万方期刊数据库(Wanfang database)、重庆维普中文科技期刊数据库(VIP)、中国生物医学数据库(CBM Disc)、Pubmed、Cochrane Library、Embase、Web of Knowledge,检索时限为2004年1月至2017年3月,纳入中药或中成药与西医对照治疗少弱精子症的临床随机对照试验,使用STATA 12.0软件对总有效率、精液量、精子密度、A级精子、(A+B)级精子等结局指标进行Meta分析。结果 共纳入44篇研究,4 779例。Meta分析结果显示,总有效率[RR=1.15,95%CI(1.07-1.23),P=1.00]、精液量[MD=0.57,95%CI(0.44-0.70),P<0.000 01]、精子密度[MD=0.82,95%CI(0.73-0.91),P<0.000 01]、A级精子[MD=0.72,95%CI(0.60-0.84),P<0.000 01]、(A+B)级精子[MD=0.85,95%CI(0.74-0.96),P<0.000 01]。结论 中医药在提高精液量、精子密度、A级精子、(A+B)级精子、治愈率等指标上优于西医疗法。

关键词: 少弱精子症, 不育, 中医药, Meta分析

Abstract: Objective To evaluate the effectiveness of traditional Chinese medicine in the treatment of oligospermia and asthenospermia. Methods Randomized controlled trials (RCTs) were retrieved from CNKI, Wanfang database, VIP, CBM, PubMed, Cochrane library, EMbase, Web of Knowledge. The date of publication was January 2004 to March 2017. RCTs about traditional Chinese medicine in the treatment of oligospermia and asthenospermia were included. Treatment group received traditional Chinese medicine, while the control group was treated with Western medicine. The quality of included studies was evaluated and performed by using the statistical software STATA12.0. Results A total of 44 RCTs involving 4779 patients were included. Meta-analysis showed that total effective rate [RR=1.15, 95%CI (1.07-1.23), P=1.00], semen volume [MD=0.57, 95%CI (0.44-0.70), P<0.000 01], sperm density [MD=0.82, 95%CI (0.73-0.91), P<0.000 01], percentage of class A sperm [MD=0.72, 95%CI (0.60-0.84), P<0.000 01], percentage of class A + B sperm [MD=0.85, 95%CI (0.74-0.96), P<0.000 01]. Conclusion Traditional Chinese medicine was superior to Western medicine in improving semen volume, sperm density, percentage of class A sperm, percentage of class A + B sperm, and total effective rate.

Key words: oligospermia, asthenospermia, infertility, traditional Chinese medicine, meta-analysis

中图分类号: 

  • R256.56