主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2018, Vol. 41 ›› Issue (10): 873-880.doi: 10.3969/j.issn.1006-2157.2018.10.014

• 临床研究 • 上一篇    

复方皂矾丸或联合西药治疗血液病疗效和安全性的Meta分析*

张稚淳1, 张晓波2, 丁皓1, 贾梦冉1, 王冲1, 陈信义1, 田劭丹1#   

  1. 1 北京中医药大学东直门医院 北京 100700;
    2 内蒙古自治区呼伦贝尔市扎兰屯市成吉思汗镇中心卫生院
  • 收稿日期:2018-02-24 出版日期:2018-10-30 发布日期:2018-10-30
  • 通讯作者: 田劭丹,女,博士,主任医师,硕士生导师,研究方向:中医药防治血液肿瘤疾病研究,E-mail:oliviastd@126.com
  • 作者简介:张稚淳,女,在读硕士生
  • 基金资助:
    国家中医药管理局中医药行业科研专项资助项目(No.201407001)

Meta-analysis of the efficacy and safety of compound Zaofan Pills alone or combined with Western medicine in the treatment of blood diseases*

Zhang Zhichun1, Zhang Xiaobo2, Ding Hao1, Jia Mengran1, Wang Chong1, Chen Xinyi1, Tian Shaodan1#   

  1. 1 Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China;
    2 Chengji Si Khan Town Center Health Center, Zhalantun, Hulunbuir City, Inner Mongolia 162691, China
  • Received:2018-02-24 Online:2018-10-30 Published:2018-10-30

摘要: 目的 系统评价复方皂矾丸或联合西药治疗血液病的疗效和安全性。方法 计算机检索国内外常用七大权威数据库,收集从建库至2018年1月间复方皂矾丸或联合西药治疗血液病的随机对照临床试验相关文献,对其进行数据提取和质量评价,采用Review Manager 5.3软件进行Meta分析。结果 最终纳入15篇合格文献,再生障碍性贫血11篇,骨髓增生异常综合征3篇,免疫性血小板减少症1篇。Meta分析结果显示:①总体疗效评价显示复方皂矾丸或联合西药明显优于单纯西药(P<0.000 01)。②复方皂矾丸或联合西药治疗再生障碍性贫血疗效优于单纯西药(P<0.000 01)。③复方皂矾丸或联合西药治疗骨髓增生异常综合征疗效优于单纯西药(P=0.002)。④有6篇文献报道了治疗相关不良反应,主要为轻度消化道反应和轻度肝功能损害,但均发生在联合用药组,故不能确定为复方皂矾丸导致。结论 复方皂矾丸或联合西药治疗再生障碍性贫血、骨髓增生异常综合征疗效优于单纯西药治疗,具有良好的安全性。

关键词: 复方皂矾丸, 再生障碍性贫血, 骨髓增生异常综合征, Meta分析

Abstract: Objective To evaluate the efficacy and safety of compound Zaofan pills alone or combined with Western medicine in the treatment of blood diseases. Methods The researchers retrieved the seven authoritative databases commonly used, and searched published randomized controlled clinical trials on compound Zaofan pills alone or combined with Western medicine in the treatment of blood diseases from the establishment of the library to January 2018, and carried out data extraction and quality evaluation, and then the Review Manager 5.3 software was used for Meta analysis. Results Finally, 15 qualified clinical studies were included, among which 11 were aplastic anemia, 3 were myelodysplasia syndromes, and 1 was immune thrombocytopenia. Meta-analysis showed that: ①The overall efficacy evaluation showed that the compound Zaofan pills alone or combined with Western medicine was superior to Western medicine alone (P<0.000 01). ②The efficacy of compound Zaofan pills alone or combined with Western medicine in the treatment of aplastic anemia was better than that of Western medicine alone (P<0.000 01).③The efficacy of compound Zaofan pills alone or combined with Western medicine in the treatment of myelodysplastic syndrome was better than that of Western medicine alone (P=0.002).④Six studies reported treatment-related adverse reactions, mainly mild gastrointestinal reaction and mild liver function damage, but all of them occurred in the combined treatment group, so it could not be determined as the result of compound Zaofan pills. Conclusion Compound Zaofan pills alone or combined with Western medicine seems to be more effective than Western medicine alone in the treatment of aplastic anemia and myelodysplastic syndrome with safety.

Key words: Compound Zaofan Pill, aplastic anemia, myelodysplastic syndromes, meta analysis

中图分类号: 

  • R255.7