主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2019, Vol. 42 ›› Issue (1): 8-11.doi: 10.3969/j.issn.1006-2157.2019.01.002

• 理论研究 • 上一篇    下一篇

糖尿病肾病“精损络痹”病机探讨

胡济源1, 柳红芳2#, 张向伟3   

  1. 1 安徽中医药大学 安徽 230038;
    2 北京中医药大学东直门医院;
    3 首都医科大学石景山教学医院 北京市石景山医院
  • 收稿日期:2018-06-06 出版日期:2019-01-30 发布日期:2019-03-01
  • 通讯作者: 柳红芳,女,博士,主任医师,博士生导师,研究方向:肾病内分泌疾病的中西医治疗,E-mail: lhfdoctor@126.com
  • 作者简介:胡济源,男,在读本科生
  • 基金资助:
    国家自然科学基金资助项目(No.81774273),北京市科学技术委员会十病十药研发项目(No.Z161100001816003)

Pathogenesis of diabetic nephropathy with essence depletion and collateral impediment

Hu Jiyuan1, Liu Hongfang2#, Zhang Xiangwei3   

  1. 1 Anhui University of Traditional Chinese Medicine, Anhui 230038, China;
    2 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700,China;
    3 Shijingshan Teaching Hospital of Capital University of Medical Sciences, Beijing 100043, China
  • Received:2018-06-06 Online:2019-01-30 Published:2019-03-01
  • Contact: Liu Hongfang, female, PhD., Chief-Physician. Research direction: treatment of endocrine diseases in kidney by traditional Chinese and Western medicine. E-mail: lhfdoctor@126.com
  • Supported by:
    National Natural Science Foundation of China (No. 81774273), Beijing Science and Technology Commission Ten Diseases & Ten medicinals Research and Development Project(No.Z161100001816003)

摘要: 糖尿病肾病的核心病机可以概括为精损络痹。强调病变以肾为核心,肾虚以精损为要,精损指肾精虚损。络痹指因虚而滞,湿、瘀、浊等邪痹阻肾络,甚则化生癥瘕,具有因虚至实的特点。据此提出以填精通络为核心治法治疗糖尿病肾病,填精即填补肾精,通络即祛邪通络。填补肾精是治疗糖尿病肾病的基石,在疾病中后期的应用尤为突出。祛邪通络包括早期重视祛邪除痹的消通之法及后期重视扶正祛邪的补通之法,祛邪而不伤正。

关键词: 糖尿病肾病, 核心病机, 精损, 络痹, 肾精

Abstract: The pathogenesis of essence depletion and collateral impediment can summarize the characteristics of core pathogenesis of diabetic nephropathy (DN) and guide clinical treatment effectively. The pathogenesis of essence depletion emphasizes that kidney lesions is the core of five viscera lesions. Kidney deficiency indicates the consumption of kidney essence and deficiency induces the production of stagnation, dampness, stasis and turbidity. The pathogenesis of collateral impediment indicates that dampness, stasis and turbidity due to deficiency obstruct kidney collateral, even aggregation-accumulation is produced. Therefore collateral impediment is characterized by excess due to deficiency. The therapy of filling essence and freeing collaterals is proposed for DN treatment in the paper. The filling essence refers to nourishing kidney essence, and freeing collaterals refers to eliminating pathogens to free collaterals. It is a kernel therapy for DN. The nourishing kidney essence is a cornerstone in DN treatment, especially in middle or late stages of DN treatment. In early stage eliminating pathogens to resolve impediment (eliminating-freeing therapy) is stressed, and in late stage reinforcing healthy qi and eliminating pathogens (nourishing-freeing therapy) is emphasized. The healthy qi will not be damaged during eliminating pathogens.

Key words: diabetic nephropathy, core pathogenesis, essence depletion, collateral impediment, kidney essence

中图分类号: 

  • R256.5