主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2019, Vol. 42 ›› Issue (1): 58-62.doi: 10.3969/j.issn.1006-2157.2019.01.010

• 中药药理 • 上一篇    下一篇

线叶金雀花与藏红花水提取物抗疲劳的作用研究*

马青, 范春兰, 唐民科#   

  1. 北京中医药大学中药学院 北京 102488
  • 收稿日期:2018-06-01 出版日期:2019-01-30 发布日期:2019-03-01
  • 通讯作者: 唐民科,男,博士,教授,博士生导师,研究方向:神经药理学,E-mail: tangmk@ bucm.edu.cn
  • 作者简介:马青,女,在读博士生
  • 基金资助:
    国家科技重大专项“重大新药创制”项目(No.2011ZX09201-201-22)

Anti-fatigue effects of aqueous extracts from Xianye Jinquehua and Zanghonghua

Ma Qing, Fan Chunlan, Tang Minke#   

  1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
  • Received:2018-06-01 Online:2019-01-30 Published:2019-03-01
  • Contact: Tang Minke, male, PhD., Professor, Doctoral Supervisor. Research direction: neuropharmacology. E-mail: tangmk@ bucm.edu.cn
  • Supported by:
    Drug Discovery Initiative of Ministry of Science and Technology (No. 2011ZX09201-201-22)

摘要: 目的 研究线叶金雀花与藏红花水提物的抗疲劳作用。方法 先将32只小鼠随机分为空白对照组、线叶金雀花组、藏红花组,灌胃给药,1次/d,14 d后进行负重游泳实验。然后,将46只小鼠随机分为空白对照组、线叶金雀花+藏红花低剂量组,灌胃给药,1次/d,14 d后进行负重游泳实验并检测血清乳酸含量。根据上述实验结果,将100只小鼠随机分为空白对照组、线叶金雀花+藏红花低剂量组、线叶金雀花+藏红花中剂量组、线叶金雀花+藏红花高剂量组,灌胃给药14 d后,检测肝糖原、肌糖原的含量。结果 单独灌胃线叶金雀花、藏红花水提物均不能增加小鼠负重游泳时间,低剂量线叶金雀花与藏红花合用能够延长小鼠负重游泳时间(P<0.05),减少血清乳酸含量(P<0.05)。与空白对照组相比,线叶金雀花+藏红花低、中、高剂量组均能增加小鼠肝脏糖原和肌肉糖原含量(P<0.05或P<0.01)。结论 线叶金雀花、藏红花水提物单独给予不具有抗疲劳作用,而二者联合则具有抗疲劳作用。

关键词: 线叶金雀花, 藏红花, 负重游泳, 血清乳酸, 肝糖原, 肌糖原, 抗疲劳作用, 小鼠

Abstract: Objective To study the anti-fatigue effects of aqueous extracts from Xianye Jinquehua (Rooibos, Aspalathus Linears) and Zanghonghua (Saffron, Crocus sativus L.) through classic behavior test (loaded swimming) and detections of blood lactic acid, liver glycogen and muscle glycogen. Methods At first 32 mice were randomly divided into blank control group, Xianye Jinquehua group and Zanghonghua group, and were orally given corresponding medicinals once a day. The test of loaded swimming was conducted in all groups after 14 d. Then 46 mice were randomly divided into blank control group and low-dose Xianye Jinquehua+Zanghonghua group, and were orally given corresponding medicinals once a day. The test of loaded swimming and detection of blood lactic acid were conducted in all groups after 14 d. According to above test results, 100 mice were randomly divided into blank control group, low-dose Xianye Jinquehua+Zanghonghua group, mid-dose Xianye Jinquehua+Zanghonghua group and high-dose Xianye Jinquehua+Zanghonghua group. After oral medication for 14 d, the content of liver glycogen and muscle glycogen was detected. Results The time of loaded swimming was not improved in Xianye Jinquehua group and Zanghonghua group, and it was prolonged (P<0.05) and content of blood lactic acid was decreased (P<0.05) in low-dose Xianye Jinquehua+Zanghonghua group. The content of liver glycogen and muscle glycogen was increased in low-dose Xianye Jinquehua+Zanghonghua group, mid-dose Xianye Jinquehua+Zanghonghua group and high-dose Xianye Jinquehua+Zanghonghua group compared with blank control group (P<0.05 or P<0.01). Conclusion The single administration of single Xianye Jinquehua or single Zanghonghua has no anti-fatigue effect, while combination of them has this effect.

Key words: Xianye Jinquehua (Rooibos, Aspalathus Linears), Zanghonghua (Saffron, Crocus sativus L.), loaded swimming, blood lactic acid, liver glycogen, muscle glycogen, anti-fatigue effect, mice

中图分类号: 

  • R285.5