主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2019, Vol. 42 ›› Issue (3): 243-247.doi: 10.3969/j.issn.1006-2157.2019.03.010

• 临床研究 • 上一篇    下一篇

虫类药治疗缺血性中风的配伍增效应用

邵婧怡1, 周玲名1, 马小雅1, 丁敏芮1, 周亚军1, 金竹青2#   

  1. 1 浙江中医药大学第一临床医学院 浙江 310053;
    2 浙江中医药大学基础医学院
  • 收稿日期:2018-09-22 出版日期:2019-03-30 发布日期:2019-04-02
  • 通讯作者: # 金竹青,女,博士,副教授,主要研究方向:中医药防治神经疾病机理,E-mail:jinzq@hotmail.com
  • 作者简介:邵婧怡,女,在读本科生
  • 基金资助:
    国家自然科学基金资助项目(No.81774010)

Combination of insect medicinals for improving curative effect applied in treatment of ischemic stroke*

Shao Jingyi1, Zhou Lingming1, Ma Xiaoya1, Ding Minrui1, Zhou Yajun1, Jin Zhuqing2#   

  1. 1 First School of Clinical Medicine, Zhejiang Chinese Medicine University, Zhejiang 310053, China;
    2 School of Basic Medicine, Zhejiang Chinese Medicine University, Zhejiang 310053, China
  • Received:2018-09-22 Online:2019-03-30 Published:2019-04-02
  • Contact: A/Prof. Jin Zhuqing, Ph.D., School of Basic Medicine, Zhejiang Chinese Medicine University. E-mail: jinzq@hotmail. com
  • Supported by:
    National Natural Science Foundation of China (No. 81774010)

摘要: 目的 通过文献探究运用虫类药治疗缺血性中风的配伍特点及其临床增效应用。方法 研究20072018年近10年的所有虫类药治疗缺血性中风的临床研究文献,采用Excel 2010建立数据库,用SPSS 24统计软件对药物使用频次进行统计分析以及聚类分析,运用RapidMiner软件对药物进行关联分析。结果 研究最终纳入156篇合格文献,方剂共计150首,药物共计153 种,合计治疗患者8 561例。其中地龙、水蛭、全蝎等虫类药出现频率最高,且经常作为药对使用;补虚、活血、化痰、清热药最常与虫类药配伍。结论 地龙水蛭全蝎药对临床较为常用以增强疗效;虫类药与补虚、活血、化痰、清热四类药配伍使用最能够加大活血化瘀、化痰通络之力。

关键词: 虫类药, 缺血性中风, 增效

Abstract: Objective To study the combination characteristics of insect medicinals in treatment of ischemic stroke, and discuss the combination methods of insect medicinal for improving clinical efficacy based on literature study. Methods All clinical research literatures resent 10 years (from 2007 to 2018) on insect medicinals were studied in, and a database was established by applying Excel 2010. The frequency of medicinal administration was statistically analyzed and given cluster analysis by using SPSS 24 software, and RapidMiner software was used in association analysis of insect medicinals. Results There were totally 156 eligible literatures, 150 formulas, 153 medicinals and 8 561 patients involved in the study. Among all insect medicinal, the appearance frequency of Dilong (Earthworm, Lurmbricus), Shuizhi (Leech, Hirudo) and Quanxie (Scorpion, Scorpio) were the highest, and they were commonly used as couplet medicinals. The medicinals with effects of tonifying deficiency, activating blood, resolving phlegm and clearing heat were often combined with sectic medicinals in administration. Conclusion The couplet medicinals of Dilong-Shuizhi-Quanxie are commonly used for improving clinical efficacy. The insect medicinal are combined with medicinals with effects of tonifying deficiency, activating blood, resolving phlegm and clearing heat can promote the effects of activating blood and resolving stasis, and resolving phlegm and free collateral.

Key words: insect medicinals, ischemic stroke, improving clinical efficacy

中图分类号: 

  • R255.2