主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2019, Vol. 42 ›› Issue (6): 502-507.doi: 10.3969/j.issn.1006-2157.2019.06.012

• 临床研究 • 上一篇    下一篇

晚期恶性肿瘤患者凝血指标异常及血瘀证分布的临床研究*

陈美云1,2, 唐德才1,2,3#   

  1. 1 南京中医药大学第二附属医院 江苏 210017;
    2 江苏省第二中医院;
    3 南京中医药大学
  • 出版日期:2019-06-05 发布日期:2019-06-05
  • 通讯作者: 唐德才,男,博士,教授,博士生导师,研究方向:中药药性、配伍机制及临床应用研究,E-mail: talknow@njucm.edu.cn
  • 作者简介:陈美云,女,硕士,副主任中医师
  • 基金资助:
    国家自然科学基金面上项目(No.81873021)

Clinical analysis of abnormal coagulation parameters and blood stasis symptoms in patients with advanced malignant tumors*

Chen Meiyun1,2, Tang Decai1,2,3#   

  1. 1 Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210017, Jiangsu;
    2 Second TCM Hospital of Jiangsu Province;
    3 Nanjing University of Chinese Medicine, Nanjing 210017, Jiangsu
  • Online:2019-06-05 Published:2019-06-05
  • Contact: Prof. Tang Decai, Ph.D., Doctoral Supervisor. Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, Jiangsu Province. E-mail: talknow@njucm.edu.cn

摘要: 目的 探讨晚期恶性肿瘤患者凝血指标异常及中医血瘀证分布的相关性。方法 通过回顾性调查,收集明确诊断为肺癌、胃癌、大肠癌、肝癌、胰腺癌、乳腺癌患者的临床资料,对不同肿瘤、好转出院及死亡患者凝血指标及血瘀证分布进行比较分析。结果 恶性肿瘤患者普遍存在凝血异常,多数患者合并有血瘀证,其中,胰腺癌血瘀证最多,乳腺癌最少。87.2%晚期恶性肿瘤患者存在凝血异常,好转出院组与死亡组比较,差异有统计学意义(P<0.05),凝血指标中纤维蛋白原、D-二聚体异常升高所占比例最多,不同肿瘤之间比较,差异有统计学意义(P<0.05) ; 83.8% 晚期恶性肿瘤患者中医辨证属于血瘀证,好转出院组与死亡组比较差异有统计学意义(P<0.05),不同肿瘤之间比较,差异有统计学意义(P<0.05) ,且与凝血指标异常存在相关性(P<0.05)。结论 凝血功能异常及血瘀证与肿瘤预后有关,血瘀证与凝血异常存在相关性,提示改善恶性肿瘤血瘀证患者的凝血功能对预后具有积极的意义。

关键词: 晚期恶性肿瘤, 凝血指标, 血瘀证

Abstract: Objective To investigate the coagulation parameters in patients with advanced malignant tumors, and their correlation with blood stasis pattern distribution in traditional Chinese medicine.Methods Through retrospective investigation, the clinical data of patients with lung cancer, gastric cancer, colorectal cancer, liver cancer, pancreatic cancer and breast cancer were collected. A comparative analysis was made of the coagulation parameters and blood stasis pattern of patients with different types of tumors, patients that got improved and discharged and those who passed away.Results Abnormal coagulation is common in patients with malignant tumors. Most patients have blood stasis pattern at the same time. Among patients with different types of cancers, those with pancreatic cancer are the most likely to have blood stasis pattern and those with breast cancer the least likely. 87.2% of patients with advanced malignant tumors had abnormal coagulation, and there was significant difference between the improved and discharged group and the deceased group (P<0.05). Patients with abnormal elevation of FIB and D-D account for the largest proportions, and there was significant difference among patients with different types of tumors (P<0.05). 83.8% of patients were diagnosed with blood stasis pattern according to TCM pattern differentiation. The difference between the improved and discharged group and the deceased group was statistically significant (P<0.05), and the difference between patients with different tumors was statistically significant (P<0.05). There was a correlation between abnormal coagulation parameters and blood stasis pattern (P<0.05).Conclusion Disorders of coagulation and blood stasis pattern are related to the prognosis of tumors, and blood stasis pattern is related to coagulation.It indicates that improving the coagulation parametres in patients with malignant tumor and blood stasis pattern may play a positive role in their prognosis.

Key words: advanced malignant tumor, coagulation parameter, blood stasis pattern

中图分类号: 

  • R255.7