主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2019, Vol. 42 ›› Issue (6): 508-513.doi: 10.3969/j.issn.1006-2157.2019.06.013

• 临床研究 • 上一篇    下一篇

降糖通络饮II号方联合甲钴胺片治疗糖尿病周围神经病变的临床效果及对血清IL-1β、sVCAM-1、HCY水平的影响

马珑, 韩永丽, 陈松#   

  1. 湖北中医药大学针灸治未病湖北省协同创新中心 湖北 430061
  • 出版日期:2019-06-05 发布日期:2019-06-05
  • 通讯作者: 陈松,男,博士,讲师,研究方向:针灸效应的基础研究,E-mail: 362573836@qq.com
  • 作者简介:马珑,男,主治医师
  • 基金资助:
    国家自然科学基金资助项目(No.81774420,No.81574065)

Effects of Jiangtang Tongluo Decoction II and mecobalamin tablets on serum IL-1β,sVCAM-1 and HCY levels in the treatment of diabetic peripheral neuropathy*

Ma Long, Han Yongli, Chen Song#   

  1. Hubei Provincial Collaborative Innovation Center for Disease Prevention with Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Hubei 430061, China
  • Online:2019-06-05 Published:2019-06-05
  • Contact: Lecturer Chen Song, Ph.D., Hubei University of Chinese Medicine, 188 Changhualin, Liaodao Street, Wuchang District, Wuhan 430061, Hubei Province. E-mail:362573836@qq.com

摘要: 目的 观察降糖通络饮II号方联合甲钴胺片治疗糖尿病周围神经病变的临床效果及对血清白细胞介素-1β(IL-1β)、可溶性血管细胞黏附分子-1(sVCAM-1)、同型半胱氨酸(HCY)含量的影响。方法 将湖北中医药大学黄家湖校医院收治的糖尿病周围神经病变、中医辨证为阴虚血瘀证的患者96例随机分为对照组和观察组,每组各48例。对照组患者给予甲钴胺片口服;观察组患者在对照组的基础上给予降糖通络饮II号方联合治疗,2周为1个疗程,连续治疗2个疗程。通过糖脂代谢、神经传导速度变化比较2组的临床疗效,并监测血清中IL-1β、sVCAM-1、HCY含量。结果 观察组有效率为91.7%,较对照组(77.1%)升高(P<0.05);治疗后与对照组相比,观察组患者的FPG、HbA1c、TC、TG、LDL-C水平降低,HDL-C水平升高(P<0.05),正中神经、腓总神经的神经传导速度均升高(P<0.05),外周血IL-1β、sVCAM-1、HCY水平降低(P<0.05)。结论 降糖通络饮II号方可改善糖尿病周围神经病变阴虚血瘀证患者的糖脂代谢,提高神经传导速度,其机制可能是通过下调外周血中IL-1β、sVCAM-1、HCY水平以减轻微血管的内皮细胞损伤而实现的。

关键词: 降糖通络饮II号方, 甲钴胺片, 糖尿病周围神经病变, 白细胞介素-1β, 可溶性血管细胞黏附分子-1, 同型半胱氨酸

Abstract: Objective To observe the clinical efficacy and influence of Jiangtang Tongluo (Anti-diabetic Vessel-dredging) Decoction II and mecobalamin tablets on serum IL-1β,sVCAM-1 and HCY levels in the treatment of diabetic peripheral neuropathy.Methods 96 cases of diabetic peripheral neuropathy diagnosed as yin deficiency with blood stasis pattern in Huangjiahu Infirmary of Hubei University of Chinese Medicine were randomly divided into a control group (n=48) and an observation group (n=48). Both groups received mecobalamin tablets while the patients in the observation group were given Jiangtang Tongluo Decoction II for 4 consecutive weeks (2 weeks as one treatment course). Glucolipid metabolism and nerve conduction velocity were measured for efficacy evaluation, the levels of serum IL-1β,sVCAM-1 and HCY being monitored.Results Effective rate was 91.7% in the observation group, which was higher than that (77.1%) of the control group (P<0.05). The improvement of glucolipid metabolism in patients of the observation group were better than those of the control group, as the levels of FPG, HbA1c, TC ,TG and LDL-C were lower than those of the control group with the higher level of HDL-C(P<0.05), the nerve conduction velocity of median nerve and peroneal nerve was significantly increased(P<0.05), and the levels of serum IL-1β,sVCAM-1 and HCY for patients in the observation group were lower than those of the control group after treatment(P<0.05).Conclusion This formula seems to improve the glycemic metabolism and to increase the rate of nerve conduction. Its mechanism might be related to decreasing the levels of serum IL-1β,sVCAM-1 and HCY to reduce the damage to the endothelial cells.

Key words: Jiangtang Tongluo Decoction II, mecobalamin tablets, diabetic peripheral neuropathy, IL-1β, sVCAM-1, HCY

中图分类号: 

  • R255.4