主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2019, Vol. 42 ›› Issue (7): 560-565.doi: 10.3969/j.issn.1006-2157.2019.07.007

• 中药药理 • 上一篇    下一篇

阿萨伊及其醇提物对虚热及虚寒证小鼠免疫因子、内分泌激素及神经递质的影响*

李伟1, 周雪1, 乐娜1, 侯燕1, 瞿研2, 张建军1, 贺成3, 王林元2#   

  1. 1 北京中医药大学中医学院 北京 100029;
    2 北京中医药大学中药学院;
    3 北京中医药大学北京中医药研究院
  • 收稿日期:2019-01-25 出版日期:2019-07-30 发布日期:2019-09-03
  • 通讯作者: 王林元,男,硕士,副教授,主要研究方向:中药新技术新制剂研究与应用,E-mail:wanglinyuan110@vip.163.com
  • 作者简介:李伟,男,高级实验师
  • 基金资助:
    国家自然科学基金资助项目(No.81173569),北京中医药大学中青年教师自主课题(No.2018-JYBZZ-JS028,No.2016-JYB-JSPY-013)

Effects of Açaí and its alcohol extract on the immunity, endocrine hormone and neurotransmitter of mice with deficiency-heat and deficiency-cold pattern*

Li Wei1, Zhou Xue1, Yue Na1, Hou Yan1, Qu Yan2, Zhang Jianjun1, He Cheng3, Wang Linyuan2#   

  1. 1 School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
    2 School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China;
    3 Beijing Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2019-01-25 Online:2019-07-30 Published:2019-09-03
  • Contact: A/Professor. Wang Linyuan, Master, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029. E-mail: wanglinyuan110@vip.163.com.

摘要: 目的 探讨阿萨伊醇提物对虚热及虚寒证小鼠免疫因子、内分泌激素及神经递质的影响及阿萨伊寒凉药性的物质基础。方法 将昆明种雄性小鼠随机分为正常组、虚热模型组、虚热阿萨伊组、虚热阿萨伊醇提物组、虚寒模型组、虚寒肉桂组、虚寒阿萨伊组、虚寒阿萨伊醇提物组。虚热组小鼠每天下午灌胃给予甲状腺片溶液160 mg/kg,虚寒组小鼠给予氢化可的松溶液25 mg/kg,连续14 d,各给药组灌胃相应药物(阿萨伊 4 g/kg,肉桂 37.5 g/kg)。采用同类比较、异类反证的方法,测定免疫因子、内分泌激素及神经递质水平等相关指标的含量变化。结果 阿萨伊醇提物与阿萨伊作用趋势一致,能改善小鼠自主活动增加、易被激惹、反应活跃等虚热症状,能降低免疫球蛋白(IgG)、补体C3(C3)、补体C4(C4)(P<0.01、P<0.001、P<0.01)等免疫因子含量,能升高皮质酮(CORT)、降低雌二醇(E2)、升高5-羟色胺(5-HT)、降低去甲肾上腺素(NE)含量(P<0.001),对虚热模型有作用,同肉桂作用相反;对虚寒模型无明显作用。结论 阿萨伊醇提物为阿萨伊寒凉药性的物质基础。

关键词: 阿萨伊, 阿萨伊醇提物, 免疫因子, 内分泌激素, 神经递质, 物质基础, 小鼠

Abstract: Objective To investigate the immunity, endocrine hormone and neurotransmitter of Açaí alcohol extract on deficiency-heat and deficiency-cold models and to clarify the material basis of the cool properties of Açaí. Methods KM male mice were randomly divided into normal group, deficiency-heat model group, deficiency-heat + Açaí group, deficiency-heat + Açaí alcohol extract group, deficiency-cold model group, deficiency-cold + cinnamon group, deficiency-cold +Açaí group, deficiency-cold +Açaí alcohol extract group. The mice were administered orally at the dose of 160 mg/kg thyroxine and 25 mg/kg hydrocortisone in the afternoon per day for 14 days to induce deficiency-heat and deficiency-cold models respectively; each administration group was given the corresponding medication. At the end of the experiment, changes of related immune factors, endocrine hormones and neurotransmitter were measured. Results Consistent with Açaí, Açaí alcohol extract can improve the symptoms of asthenia fever, such as increased autonomous activity, easily irritated and active reaction in mice. It can reduce the level of immune factors such as IgG, C3, C4 (P<0.01, P<0.001, P<0.01), increase CORT (P<0.01), decrease E2 (P<0.01), elevate 5-HT (P<0.01), and reduce the NE content (P<0.001). Açaí alcohol extract had an effect on deficiency-heat model, in contrast to cinnamon, while there was no significant effect on the deficiency-cold model. Conclusion The alcohol extract of Açaí is the material basis of the cool properties of Açaí.

Key words: Açaí, Açaí alcohol extract, immune factor, endocrine hormone, neurotransmitter, material basis, mice

中图分类号: 

  • R285.5