主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2019, Vol. 42 ›› Issue (9): 773-777.doi: 10.3969/j.issn.1006-2157.2019.09.012

• 临床研究 • 上一篇    下一篇

浅谈抑郁症脾虚病机与线粒体能量代谢障碍的相关性*

刘姝含1, 郭蓉娟2#, 于姚1, 任非非1, 李阳1   

  1. 1 北京中医药大学 北京 100029;
    2 北京中医药大学东方医院
  • 收稿日期:2019-05-07 出版日期:2019-09-30 发布日期:2019-09-27
  • 通讯作者: 郭蓉娟,女,博士,教授,博士生导师,研究方向:中医药防治脑病,E-mail:dfguorongjuan@163.com
  • 作者简介:刘姝含,女,在读博士生
  • 基金资助:
    国家自然科学基金面上项目(No. 81874422)

Relationship between pathogenesis of spleen deficiency in depression and mitochondrial energy metabolism disorder*

Liu Shuhan1, Guo Rongjuan2#, Yu Yao1, Ren Feifei1, Li Yang1   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China
  • Received:2019-05-07 Online:2019-09-30 Published:2019-09-27
  • Contact: Prof. Guo Rongjuan, Ph. D., Chief Physician, Doctoral Supervisor. Dongfang Hospital of Beijing University of Chinese Medicine. No. 6, Fangzhuang Fangxingyuan Yiqu, Fengtai District, Beijing 100078. E-mail: dfguorongjuan@163.com
  • Supported by:
    National Natural Science Foundation of China (No. 81874422)

摘要: 抑郁症是以情绪低落、思维迟缓、意志活动减退为主要特征的综合征。抑郁症脾虚是中医临床的常见证候,是抑郁症的重要病机,线粒体能量代谢障碍参与了抑郁症的病理生理过程,且脾虚病机的产生与线粒体能量代谢障碍存在密切的相关性,中医健脾益气药对抑郁症及线粒体损伤的改善作用明显。

关键词: 抑郁症, 脾虚, 线粒体, 能量代谢, 健脾益气

Abstract: Depression is a syndrome characterized by low spirit, mental retardation and decreased volitional activity. As a common TCM clinical pattern related to depression, spleen deficiency is an important pathogenesis of depression. Mitochondrial energy metabolism disorder often exists in the pathophysiological process of depression. The pathogenesis of spleen deficiency is closely related to mitochondrial energy metabolism disorder. Spleen-fortifying qi-boosting medicinals have obvious effects on depression and mitochondrial damage.

Key words: depression, spleen deficiency, mitochondria, energy metabolism, spleen-fortifying qi-boosting

中图分类号: 

  • R277.749