主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2019, Vol. 42 ›› Issue (9): 778-786.doi: 10.3969/j.issn.1006-2157.2019.09.013

• 临床研究 • 上一篇    下一篇

基于关联随机模型研究雷公藤不同制剂对类风湿关节炎患者抗氧化免疫炎症指标的影响*

郭锦晨1,2, 刘健3#, 王键1,2, 张晓军1, 忻凌3, 黄旦3, 周巧1   

  1. 1 安徽中医药大学 安徽 230038;
    2 新安医学教育部重点实验室;
    3 安徽中医药大学第一附属医院
  • 收稿日期:2019-03-12 出版日期:2019-09-30 发布日期:2019-09-27
  • 通讯作者: 刘健,男,主任医师,教授,博士生导师,研究方向:中医药防治风湿病,E-mail:liujianahzy@126.com
  • 作者简介:郭锦晨,男,在读博士生
  • 基金资助:
    中医药行业科研专项项目(No.201307001),2016年中央引导地方科技发展专项项目(No.2016-1188)

A study on effects of different preparations of tripterygium wilfordii on antioxidant and immuno-inflammatory parameters in RA patients based on a random coefficient model*

Guo Jinchen1,2, Liu Jian3#, Wang Jian1,2, Zhang Xiaojun1, Xin Ling3, Huang Dan3, Zhou Qiao1   

  1. 1 Anhui University of Chinese Medicine, Anhui 230038, China;
    2 Key Laboratory of Xin’an Medicine under Ministry of Education, Anhui 230021, China;
    3 The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui 230031, China
  • Received:2019-03-12 Online:2019-09-30 Published:2019-09-27
  • Contact: Prof. Liu Jian, Ph.D., Doctoral Supervisor. First Affiliated Hospital of Anhui University of Chinese Medicine. No. 117 Meishan Road, Shushan District, Hefei 230038. E-mail:liujianahzy@126.com
  • Supported by:
    Special Research Project of Traditional Chinese Medicine Industry (No. 201307001), 2016 Special Projects for Local Sci-tech Development Guided by the Central Government (No.2016-1188)

摘要: 目的 研究雷公藤不同制剂对类风湿关节炎(RA)患者抗氧化免疫炎症指标的影响。方法 收集安徽省中医院风湿病科2012年5月至2018年12月RA住院患者应用复方雷公藤(新风胶囊)和单味雷公藤(雷公藤多苷片)治疗的病历资料,采用SPSS 22.0分析2组RA患者抗氧化免疫炎症等指标的变化,采用SPSS Clementine 14.2软件Apriori模块、ORACLE 10 g工具进行关联规则分析、随机行走模型评价。结果 2组RA患者IgA、IgM、CCP-AB、Hs-CRP、ESR治疗前后差值均降低(P<0.01)。新风胶囊、雷公藤多苷片与免疫炎症等指标的改善均有明显关联关系,新风胶囊与SOD、IgA、IgG、IgM、RF、CCP-AB、Hs-CRP、ESR等指标改善的关联置信度明显高于雷公藤多苷片,且联合黄芪、猪苓、泽泻等中药与SOD、IgM、CCP-AB等指标改善的关联置信度明显高于雷公藤多苷片联合中药。随机行走模型分析:复方雷公藤组SOD、IgM、Hs-CRP、CCP-AB综合评价指标每正向行走一步综合改善率分别为35.10%、5.37%、27.72%、17.97%。单味雷公藤组SOD、IgM、Hs-CRP、CCP-AB综合评价指标每正向行走一步综合改善率分别为15.10%、2.10%、31.90%、22.61%。结论 雷公藤不同制剂均能有效改善类风湿关节炎患者抗氧化免疫炎症指标,且联合中药内服与指标改善存在明显关联关系。2组患者综合评价指标和接受的干预措施存在长程关联,复方雷公藤组SOD、IgM的综合评价改善优于单味雷公藤组,且安全性好。

关键词: 类风湿关节炎, 雷公藤多苷片, 新风胶囊, 抗氧化, 免疫炎症, 关联规则, 随机行走模型

Abstract: Objective To observe the effects of different preparations of tripterygium wilfordii on antioxidant and immuno-inflammatory parameters in patients with rheumatoid arthritis(RA). Methods The case records were collected of RA inpatients treated with compound tripterygium wilfordii (Xinfeng Capsule) and single tripterygium wilfordii (Tripterygium Wilfordii Polyglycoside Tablet) from May 2012 to December 2018 in Rheumatology Department, The First Affiliated Hospital of Anhui University of Chinese Medicine. SPSS 22.0 was used to analyze the changes in antioxidant and immuno-inflammatory parameters and other parameters of the two groups of RA patients. SPSS Clementine 14.2 software Apriori module and ORACLE 10g were used to identify associations and random walk model was used to evaluate the associations. Results The IgA, IgM, CCP-AB, Hs-CRP and ESR were all decreased after treatment compared with before treatment of the two groups of RA patients (P<0.01). Both Xinfeng Capsule and Tripterygium Wilfordii Polyglycoside Tablet have obvious correlation with the improvement of immuno-inflammatory parameters and other parameters. The correlation confidence of Xinfeng Capsule and the improvement of parameters like SOD, IgA, IgG, IgM, RF, CCP-AB, Hs-CRP, and ESR is significantly higher than that of Tripterygium Wilfordii Polyglycoside Tablet, and the correlation confidence of Xinfeng Capsule used in combination with such Chinese medicinal herbs as astragalus, polyporus, and alismatis and the improvement of parameters like SOD, IgM, and CCP-AB is significantly higher than that of Tripterygium Wilfordii Polyglycoside Tablet used in combination with those herbs. Random walk model analysis: The comprehensive improvement rates of SOD, IgM, Hs-CRP and CCP-AB in the compound tripterygium wilfordii group were 35.10%, 5.37%, 27.72% and 17.97% respectively for each forward step. Corresponding improvement rates in the single tripterygium wilfordii group were 15.10%, 2.10%, 31.90% and 22.61% respectively. Conclusion Different preparations of tripterygium wilfordii can effectively improve the antioxidant immuno-inflammatory parameters of patients with rheumatoid arthritis, and there is a significant correlation between oral administration of some other herbs and parameter improvement. There is a long-term correlation between the comprehensive evaluation parameters of the two groups of patients and the intervention. The comprehensive evaluation improvement of SOD and IgM in compound tripterygium wilfordii group is better than that in single tripterygium wilfordii group, and the safety is better too.

Key words: rheumatoid arthritis, Tripterygium Wilfordii Polyglycoside Tablet, Xinfeng Capsule, antioxidation, immune inflammation, association rules, random walk model

中图分类号: 

  • R259.322