主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2019, Vol. 42 ›› Issue (9): 787-792.doi: 10.3969/j.issn.1006-2157.2019.09.014

• 临床研究 • 上一篇    

非小细胞肺癌病案证素分布规律及不同方法辨证结果的对比研究*

贺佐梅1, 黄惠勇2, 郜文辉3, 徐云4, 李亮3, 邵峰3, 曾普华1#   

  1. 1 湖南省中医药研究院附属医院 湖南 410006;
    2 湖南省中医药管理局;
    3 湖南中医药大学;
    4 湘潭市第一人民医院
  • 收稿日期:2019-03-24 出版日期:2019-09-30 发布日期:2019-09-27
  • 通讯作者: 曾普华,男,博士,主任医师,研究方向:中医药防治恶性肿瘤,E-mail:zph120@126.com
  • 作者简介:贺佐梅,女,博士,住院医师
  • 基金资助:
    湖南省自然科学基金项目(No.2016JJ4067),湖南省科技计划项目(No.22016SK2034),抗肿瘤中药创制技术湖南省工程研究中心项目(No.湘发改高技2015-1085号)

Comparative study on distribution of pattern elements and results of different methods of pattern differentiation in cases of non-small cell lung cancer*

He Zuomei1, Huang Huiyong2, Gao Wenhui3, Xu Yun4, Li Liang3, Shao Feng3,Zeng Puhua1#   

  1. 1 Hunan Academy of Traditional Chinese Medicine Affiliated Hospital, Hunan 410006, China;
    2 Hunan Administration of Traditional Chinese Medicine, Hunan 410008, China;
    3 Hunan University of Chinese Medicine, Hunan 410208, China;
    4 The First People’s Hospital of Xiangtan City, Hunan 411101, China
  • Received:2019-03-24 Online:2019-09-30 Published:2019-09-27
  • Contact: Zeng Puhua, Chief Physician, Ph.D. Hunan Academy of Traditional Chinese Medicine Affiliated Hospital. No. 58 Lushan Road, Yuelu District, Changsha 410006. E-mail: zph120@126.com
  • Supported by:
    Natural Science Foundation of Hunan Province (No.2016JJ4067), Hunan Engineering Research Center Project for Anti-Tumor Chinese Herbal Medicine Innovation Technology (No. High Technology of Development and Reform Commission in Hunan 2015-1085), Science and Technology Project of Hunan Province (No.22016SK2034)

摘要: 目的 通过数据挖掘方法对非小细胞肺癌(NSCLC)病案进行挖掘,总结NSCLC的中医辨证规律,以期为NSCLC临床辨证用药提供参考。方法 一方面挖掘出7 435份NSCLC病案的四诊信息,通过“文锋-III中医(辅助)诊疗系统”进行证素辨证;另一方面将临床医师记录的病案中医辨证拆分成单一证素。挖掘出非小细胞肺癌的证素分布规律,并比较临床医师辨证和“文锋-III中医(辅助)诊疗系统”辨证的差异。结果 医师病案辨证结果表明,病位证素以脾(1 910频次)、肺(1 608频次)为主,病性证素以气虚(6 751频次)、血瘀(6 572频次)、火(热、毒)(6 331频次)、阴虚(5 657频次)、痰(1 242频次)等为主;“文锋-III中医(辅助)诊疗系统”辨证结果表明,病位证素以肺(7 371频次)、胸膈(1 837频次)、肾(1 417频次)、心(1 358频次)、胃(1 074频次)等为主,病性证素以阴虚(3 507频次)、气虚(3 323频次)、痰(3 204频次)、血瘀(2 542频次)、火(热、毒)(1 622频次)等为主。结论 肺癌的病位证素主要在肺,病性证素主要为阴虚、气虚、痰、血瘀、火(热、毒)等,并且“文锋-III中医(辅助)诊疗系统”的证素辨证结果与临床用药分布规律更契合。

关键词: 非小细胞肺癌, 证素, 辨证

Abstract: Objective To explore case records of non-small-cell lung cancer (NSCLC) through data mining to obtain laws of TCM pattern differentiation of NSCLC, which provide reference for clinical pattern differentiation and treatment of NSCLC. Methods This study excavated information obtained by four diagnostic methods of 7435 non-small cell lung cancer cases, and conducted pattern element differentiation through the “Wenfeng-III Chinese Medicine (Assisted) Diagnosis and Treatment System”. It also analyzed pattern elements from case records by clinicians. The distribution of pattern elements in non-small cell lung cancer was identified, and clinician pattern differentiation and “Wenfeng-III Chinese Medicine (Assisted) Diagnosis and Treatment System” pattern differentiation were compared to analyze the differences. Results An analysis of doctors’ pattern differentiation in case records showed that the elements concerning the location of the disease were mainly spleen (1910 times), and lung (1608). The elements related to the nature of the disease included mainly qi deficiency (6751), blood stasis (6572), fire (heat, toxin) (6331), yin deficiency (5657), and phlegm (1242). An analysis of pattern differentiation results obtained by “Wenfeng-III Chinese Medicine (Assisted) Diagnosis and Treatment System” showed that the elements concerning the location of the disease were mainly lung (7371), chest (1837), kidney (1417), heart (1358), and stomach (1074). The elements related to the nature of the disease included mainly yin deficiency (3507), qi deficiency (3323), phlegm (3204), blood stasis (2542), and fire (heat, toxin) (1622). Conclusion The element concerning the location of the lung cancer was primarily lung and the elements related to the nature of the disease included mainly yin deficiency, qi deficiency, phlegm, blood stasis, and fire (heat, toxin). The pattern differentiation results by “Wenfeng-III Chinese Medicine (Assisted) Diagnosis and Treatment System” are more in line with the distribution of clinical prescriptions.

Key words: non-small cell lung cancer, pattern element, pattern differentiation

中图分类号: 

  • R259.734