主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2020, Vol. 43 ›› Issue (2): 98-102.doi: 10.3969/j.issn.1006-2157.2020.02.002

• 理论研究 • 上一篇    下一篇

“水寒木郁”病机在帕金森病抑郁发病中的作用*

陈弘婧1,2, 李小黎1#, 刘海鹏1,2, 林亮吟1,2, 刁华琼1,2, 丁海月1,2, 魏丹1,2   

  1. 1 北京中医药大学第三附属医院 北京 100029;
    2 北京中医药大学
  • 收稿日期:2019-09-02 发布日期:2020-03-24
  • 通讯作者: 李小黎,男,博士,主任医师,博士生导师,研究方向: 中医脑病、神经药理,E-mail:tigerlxl2002@163.com
  • 作者简介:陈弘婧,女,在读硕士生
  • 基金资助:
    *首都临床特色应用研究项目(No.Z141107002514136)

Pathogenesis of “water cold resulting in inhibition of the wood” in Parkinson’s disease with depression*

Chen Hongjing1,2, Li Xiaoli1#, Liu Haipeng1,2, Lin Liangyin1,2, Diao Huaqiong1,2, Ding Haiyue1,2, Wei Dan1,2   

  1. 1 The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China;
    2 Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2019-09-02 Published:2020-03-24
  • Contact: Li Xiaoli, Ph.D.,Chief Physician, Doctoral Supervisor.The Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029, China.E-mail: tigerlxl2002@163.com
  • Supported by:
    Beijing Municipal Science & Technology Commission(No.Z141107002514136)

摘要: “水寒木郁”即指肾阳虚水寒,肝木失温,肝郁不发而为病。此病机观源于《黄帝内经》,并被后世医家发展应用于各系统疾病中。我们通过前期研究发现“水寒木郁”亦为帕金森病抑郁(PDD)发病的重要机制,其中阳虚水寒为发病之根本,肝木郁滞为发病之肇始。许多临床研究从温阳解郁的角度治疗PDD效果良好,我们也以此病机为据拟定温阳解郁方(制附子、巴戟天、柴胡等)进行研究,有效率达70%。药理学研究亦表明,一些有温肾或疏肝作用的中药能通过多个途径治疗PDD,这些研究结果反向证实了PDD“水寒木郁”病机的正确性。从历史溯源、理论探索、相关研究依据等方面阐述该病机在PDD发病中的作用,以期为PDD的病机研究及临床治疗提供新的思路和借鉴。

关键词: 帕金森病, 帕金森病抑郁, 水寒木郁, 病机

Abstract: “Water cold resulting in inhibition of the wood” refers to that kidney yang deficiency and cold coagulation in the kidney may lead to failune of the kidney to warm the liver and liver qi stagnation. This pathogenesis originated from the Huangdi Neijing (Huangdi’s Internal Classic), and has been developed and applied to diseases of various systems by later physicians. Based on literature research, it is observed that this pathogenesis could possibly be applied in interpreting the mechanism of Parkinson’s disease with depression (PDD) from TCM perspective. For PDD, yang deficiency and cold coagulation of the kidney is the root of the attack, and liver qi stagnation appears in the initial stage. According to various clinical studies, the therapeutic method of warming the kidney yang to relieve liver qi stagnation is effective in treating PDD. Based on such findings, we have developed a formula (composed of Zhifuzi (prepared aconite root, Radix Aconiti Lateralis Praeparata), Bajitian (morinda root,Radix Morindae Officinalis), Chaihu (bupleurum, Radix Bupleuri)) with corresponding effects, which proves to be 70%effective. Pharmacological studies also show that certain traditional Chinese medicinals with the effect of warming the kidney or relieving the liver qi stagnation can show some effect in the treatment of PDD. These research results support the exploration of the pathogenesis of PDD from the perspective of “water cold resulting in inhibition of the wood”. This article has explored such a pathogenesis in PDD based on literature reviews of classical TCM literature, relevant theories and modern studies, in order to provide new ideas and references for the pathogenesis research and clinical treatment of PDD.

Key words: Parkinson’s disease, Parkinson’s disease with depression, water cold resulting in inhibition of the wood, pathogenesis

中图分类号: 

  • R277.7