主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2020, Vol. 43 ›› Issue (5): 414-422.doi: 10.3969/j.issn.1006-2157.2020.05.011

• 中药预警 • 上一篇    下一篇

丹参制剂辅助治疗乳腺癌的安全风险预警研究*

王笑1, 林志健1,2, 张冰1,2#, 王雨1, 毛秋月1, 姜卓希1   

  1. 1.北京中医药大学中药学院 北京 102488;
    2.北京中医药大学中药药物警戒与合理用药研究中心
  • 收稿日期:2019-11-11 发布日期:2020-06-08
  • 通讯作者: #张冰,女,博士,教授,主任医师,博士生导师,主要研究方向:中药防治代谢性疾病研究、中药药物警戒与合理用药,E-mail:zhangbing@bucm.edu.cn
  • 作者简介:王笑,女,在读硕士生
  • 基金资助:
    *国家中医药管理局-国家中医药领军人才支持计划“岐黄学者”项目(No.10400633210004)

Early warning on safety risks of Danshen preparation in the treatment of breast cancer*

Wang Xiao1, Lin Zhijian1,2, Zhang Bing1,2#, Wang Yu1, Mao Qiuyue1, Jiang Zhuoxi1   

  1. 1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China;
    2. Center for Pharmacovigilance and Rational Use of Chinese Medicine, Beijing 102488, China
  • Received:2019-11-11 Published:2020-06-08
  • Contact: Prof. Zhang Bing, Ph. D., Doctoral Supervisor. School of Chinese Materia Medica, Beijing University of Chinese Medicine. Liangxiang Town, Fangshan District, Beijing 102488, China. E-mail: zhangbing@bucm.edu.cn
  • Supported by:
    Qihuang Scholar Project funded by National Administration of Traditional Chinese Medicine (No.10400633210004)

摘要: 目的 探讨丹参制剂辅助治疗乳腺癌的安全风险。方法 生物信息学技术筛选分析GEO数据库中的基因芯片GSE85871,对丹参制剂的主要化学成分干预人乳腺癌细胞MCF7差异表达基因进行GO功能注释和KEGG通路分析,结合文献挖掘方法梳理丹参制剂的不良反应/事件。结果 丹参制剂干预MCF7细胞时,对神经-配体信号通路、甲状腺通路、免疫调节及CHRM2等基因显示调节作用,该通路的异常会引起神经受体功能异常、下丘脑分泌功能异常(甲状腺)、呼吸系统功能异常(哮喘)。结论 初步利用生物信息学方法结合文献挖掘,预警丹参制剂辅助治疗乳腺癌的潜在安全风险,提示临床医护人员在应用丹参制剂辅助治疗乳腺癌时,应关注患者的神经系统功能、甲状腺功能、呼吸功能。为进一步中药制剂的安全性研究提供思路。

关键词: 丹参制剂, 乳腺癌, 用药风险预警

Abstract: Objective To explore the safety risk of Danshen (danshen root, Radix et Rhizoma Salviae Miltiorrhizae) preparation in the treatment of breast cancer. Methods Bioinformatics technology was used to screen and analyze the gene chip GSE85871 in the GEO database. The intervention effect of main chemical components of the Danshen preparation on the differentially expressed genes of human breast cancer cells MCF7 was analyzed with the GO function and the KEGG pathway, combined with the literature mining method to sort out the adverse reactions/events of Danshen preparation. Results When Danshen preparation interferes with the MCF7 cells, it could regulate genes such as nerve ligand signal pathway, thyroid pathway, immune regulation, and the expression of CHRM2. The abnormality of this pathway would cause abnormal neurological receptor function, hypothalamic dysfunction (thyroid), and respiratory function (asthma). Conclusion With the approaches of bioinformatics and literature mining, thisarticle explores the early warning of the potential safety risk of Danshen preparation in the adjuvant treatment of breast cancer. In the treatment of breast cancer with Danshen preparation, more attention should be paid to monitor the patient’s neurological, thyroid and respiratory functions. Thus, this article attempts to provide ideas for further study of the safety issue of TCM preparation.

Key words: Danshen (danshen root, Radix et Rhizoma Salviae Miltiorrhizae), breast cancer, drug risk warning

中图分类号: 

  • R285.6