主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2020, Vol. 43 ›› Issue (5): 427-431.doi: 10.3969/j.issn.1006-2157.2020.05.013

• 临床研究 • 上一篇    下一篇

稳定性冠心病合并脂代谢异常的中医证候分布特征*

方格, 任琦, 王彬, 周小文, 李先涛#   

  1. 广州中医药大学基础医学院 广东 510006
  • 收稿日期:2019-12-03 发布日期:2020-06-08
  • 通讯作者: #李先涛,男,博士,教授,博士生导师,主要研究方向: 临床流行病学心脑血管疾病防治应用研究、中医证候研究,E-mail:lxt150@126.com
  • 作者简介:方格,女,在读硕士生
  • 基金资助:
    *国家重点基础研究发展计划( 973 计划)项目(No. 2014CB542901)

Distribution characteristics of TCM patterns in stable coronary heart disease with dyslipidemia*

Fang Ge, Ren Qi, Wang Bin, Zhou Xiaowen, Li Xiantao#   

  1. School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangdong 510006, China
  • Received:2019-12-03 Published:2020-06-08
  • Contact: Prof. Li Xiantao, Ph. D., Doctoral Supervisor. School of Basic Medical Science, Guangzhou University of Chinese Medicine, No. 232, outer ring East Road, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. E-mail: lxt150@126.com
  • Supported by:
    National Basic Research Program of China (973 Program) (No. 2014CB542901)

摘要: 目的 探讨稳定性冠心病合并脂代谢异常的中医证候分布特征。方法 通过临床流行病学调查,采用多元统计方法,分析稳定性冠心病合并脂代谢异常的症状频次,对中医证候分布特征进行主成分分析、因子分析、聚类分析。结果 稳定性冠心病合并脂代谢异常患者的证候主成分分析,取特征值大于1的主成分,其累计贡献率为61.81%;因子分析共提取了10个公因子,对10个公因子进行聚类分析,聚为4类特征群。结论 稳定性冠心病合并脂代谢异常的中医证候分布归为4类证候群,多为本虚标实、虚实夹杂之证,本虚有阴虚及气阴两虚,标实有血瘀、痰湿,主要涉及心、脾、肾3脏,研究为提高中医辨证论治水平和临床疗效提供了参考依据。

关键词: 冠心病, 脂代谢异常, 证候, 分布

Abstract: Objective To explore the distribution characteristics of TCM patterns of stable coronary heart disease with abnormal lipid metabolism. Methods Through clinical epidemiological investigation, the distribution characteristics of TCM patterns of stable coronary heart disease with dyslipidemia were analyzed with the multivariate statistical method. Results The principal component analysis of patterns in patients with stable coronary heart disease and abnormal lipid metabolism was carried out. The principal component with eigenvalue greater than 1 was selected, and its cumulative contribution rate was 61.81%. In the factor analysis, 10 common factors were extracted and clustered into four characteristic groups under cluster analysis. Conclusion By frequency analysis, principal component analysis, factor analysis and cluster analysis, the distribution of TCM patterns of stable coronary heart disease with abnormal lipid metabolism can be classified into four types. Most of them are a mixture of deficiency and excess, with deficiency of yin or both qi and yin, and excess including blood stasis and phlegm-dampness, mainly involving the heart, spleen and kidney. This study could provide relevant references for improving TCM pattern differentiation, treatment and clinical efficacy.

Key words: coronary heart disease (CHD), abnormal lipid metabolism, patterns, distribution

中图分类号: 

  • R256.22