主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2020, Vol. 43 ›› Issue (6): 487-491.doi: 10.3969/j.issn.1006-2157.2020.06.008

• 理论研究 • 上一篇    下一篇

基于“肺与大肠相表里”探讨“肺肠合病”与黏膜免疫的关系*

郑榕, 许若缨, 柯敏辉, 汤水华, 黄铭涵#   

  1. 福建中医药大学附属第二人民医院 福建 350003
  • 收稿日期:2019-10-20 发布日期:2020-07-06
  • 通讯作者: #黄铭涵,男,硕士,副主任医师,硕士生导师,主要研究方向:慢性脾胃病研究,E-mail:huangminghan2010@163.com
  • 作者简介:郑榕,女,在读硕士生
  • 基金资助:
    *国家自然科学基金资助项目(No.81774118),福建省卫健委中青年骨干人才培养资助项目(No.2019-ZQN-79),福建中医药大学中医脾胃优势学科开放课题资助项目(No.X2019028-学科)

Exploration of relationship between the “simultaneous lung and large intestine pattern” and mucosal immunity based on the “interior-exterior relationship between the lung and large intestine”*

Zheng Rong, Xu Ruoying, Ke Minhui, Tang Shuihua, Huang Minghan#   

  1. The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fujian 350003, China
  • Received:2019-10-20 Published:2020-07-06
  • Contact: Huang Minghan, Associate Chief Physician, Master’s Supervisor. The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine. No. 282 Wusi Road, Gulou District, Fuzhou 350003. E-mail:huangminghan2010@163.com
  • Supported by:
    National Natural Science Foundation of China (No.81774118), Program for Young and Middle aged Backbone Talents funded by Fujian Provincial Health Commission (No.2019-ZQN-79)

摘要: 基于中医“肺与大肠相表里”理论,结合西医学黏膜免疫研究进展,总结“肺肠合病”和肺、肠功能、黏膜免疫之间的病理生理关系。肺主宣降,使卫气布达周身肌表;大肠传化糟粕,使五脏安定。肺与大肠生理功能正常是抵御外邪的基础条件,两者功能失常是导致“肺肠合病”的根本原因。西医学认为“肺肠合病”与黏膜免疫密切相关,黏膜免疫中免疫球蛋白、细胞因子是“肺肠合病”的物质基础,其“选择性的归巢机制”则是“肺肠合病”的桥梁。运用“肺与大肠相表里”理论,探讨“肺肠合病”与黏膜免疫的关系,可为“肺肠合病”的临床治疗提供新思路。

关键词: 肺与大肠相表里, 肺肠合病, 黏膜免疫

Abstract: Based on the theory of the “interior-exterior relationship between the lung and large intestine” in traditional Chinese medicine (TCM) and drawing on the research progress in mucosal immunology of modern medicine, the present paper summarizes the pathophysiological relationship between simultaneous lung and large intestine pattern and the function of lung and intestine as well as mucosal immunity. As lung qi disperses and descends, it makes defensive qi flow around the body surface. As large intestine transports and transforms waste substances from the body, the five zang-organs are in peace and stability. While the normal physiological function of the lung and large intestine is the foundation for body defenses against external pathogenic factors, their abnormal functioning will lead to the lung and large intestine pattern. According to modern medicine, such disease is closely related to mucosal immunity. It is believed that immunoglobulins and cytokines in the mucosal immune system might play a role in affecting both the lung and large intestine at the same time, and the selective homing mechanism could explain the transmission of the disease between the two. The present research hopes to shed some light on the clinical treatment of the lung and large intestine pattern by exploring the relationship between the disease and mucosal immunity from the perspective of the TCM theory of the “interior-exterior relationship between the lung and large intestine”.

Key words: interior-exterior relationship between the lung and large intestine, simultaneous lung and large intestine pattern, mucosal immunity

中图分类号: 

  • R221.1