主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2021, Vol. 44 ›› Issue (1): 92-96.doi: 10.3969/j.issn.1006-2157.2021.01.014

• 临床研究 • 上一篇    

从中医学视角探讨慢性胃炎“炎癌转化”过程的免疫失衡与重建*

李园1, 赵莹2, 陈萌3, 林洁3, 李涛1, 张江兰3, 褚福浩3, 邹昊婧3, 苏泽琦4, 丁霞3#   

  1. 1 北京中医药大学东直门医院 北京 100700;
    2 北京中医药大学附属第三医院;
    3 北京中医药大学中医学院;
    4 北京中医药大学北京中医研究院
  • 出版日期:2021-01-30 发布日期:2021-01-18
  • 通讯作者: #丁霞,女,博士,教授,博士生导师,主要研究方向:中西医结合防治消化系统疾病基础与临床研究,中医药抗肿瘤研究,E-mail: dingx@bucm.edu.cn
  • 作者简介:李园,女,在读博士生
  • 基金资助:
    *国家自然科学基金重点项目(No.81630080),国家重点研发计划项目(No.2018YFC1704106),国家自然科学基金青年项目(No.81703931、No.81903792)

Destruction and reconstruction of immune balance in “inflammation to cancer” of chronic gastritis from the perspective of traditional Chinese medicine*

Li Yuan1, Zhao Ying2, Chen Meng3, Lin Jie3, Li Tao1, Zhang Jianglan3, Chu Fuhao3, Zou Haojing3, Su Zeqi4, Ding Xia3#   

  1. 1 Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;
    2 Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China;
    3 School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;
    4 Beijing Research Institute of Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China
  • Online:2021-01-30 Published:2021-01-18
  • Contact: Prof.Ding Xia,Ph.D.,Doctoral supervisor.School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,No.11 Beisanhuan Dong Road.E-mail:dingx@bucm.edu.cn.
  • Supported by:
    Key Project of National Natural Science Foundation of China(No.81630080),National Key Research and Development Plan(No.2018YFC1704106),Youth Project of National Natural Science Foundation of China(No. 81703931、No. 81903792)

摘要: 阴阳消长、邪正盛衰是中医学阐释疾病发生发展规律的重要理论基础,对于认识慢性胃炎“炎癌转化”过程及防治具有重要指导意义。现代医学认为免疫系统失衡是肿瘤发生的根本原因,而免疫治疗被誉为是人类最有希望攻克癌症的手段。中医学的阴阳、正邪学说与现代医学对免疫的认识具有很多相通之处,尤其是近年来提出肿瘤免疫治疗应从“免疫增强疗法”向“免疫正常化疗法”回归的理念,与中医学“调和阴阳,扶正祛邪”以恢复人体相对平衡状态的核心思想相一致。本文在中西医理论相辅相成、相互渗透、相互促进的基础上展开论述,旨在促进祖国传统医学与现代医学在慢性胃炎“炎癌转化”发展过程及防治策略上的理论融合与发展。

关键词: 慢性胃炎, 炎癌转化, 阴阳消长, 正邪相争, 免疫平衡, 临界状态

Abstract: The growth and decline of yin and yang,and the conflict between healthy qi and pathogenic factor are important theoretical foundations for traditional Chinese medicine (TCM) to in terpret disease occurrence and development,which is of significance for guiding the understanding of “inflammation to cancer” of chronic gastritis and its prevention and treatment.From the perspective of Western medicine,the imbalance of the immune system is the root cause of tumors,and immunotherapy is hailed as the most promising means for curing cancer.The theories of yin and yang,and healthy qi and pathogenic factor of TCM have much in common with the understanding of immunity in western medicine.Especially in recent years,the idea that tumor immunotherapy should return from “immune enhancement” to “immune normalization” is similar to the core idea of “harmonizing yin and yang,reinforcing healthy qi to dispel pathogenic qi” in TCM.Based on the combination of theories from both traditional Chinese medicine and Western medicine,this paper aims to promote the theoretical integration and development of traditional Chinese medicine and Western medicine in prevention and treatment of “inflammation to cancer” of chronic gastritis.

Key words: chronic gastritis, inflammation to cancer, growth and decline of yin and yang, conflict between healthy qi and pathogenic factor, immune balance, critical state

中图分类号: 

  • R259