主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2021, Vol. 44 ›› Issue (2): 183-187.doi: 10.3969/j.issn.1006-2157.2021.02.015

• 临床研究 • 上一篇    下一篇

从正邪转化探讨肿瘤病机与治疗*

刘燕1, 吴耀松1, 刘俊1, 蒋时红2, 杨铁柱3, 任闪闪1, 陈玉龙1#   

  1. 1 河南中医药大学中医药科学院 河南省中医方证信号传导重点实验室 河南 450046;
    2 河南中医药大学研究生院;
    3 河南省洛阳正骨医院重症医学科
  • 收稿日期:2020-08-12 出版日期:2021-02-28 发布日期:2021-02-21
  • 通讯作者: #陈玉龙,男,博士,教授,博士生导师,主要研究方向:中医肿瘤方证相关研究,E-mail:cyl72621@163.com
  • 作者简介:刘燕,女,博士,实验师
  • 基金资助:
    *国家自然科学基金项目(No.81373535),河南省科技厅河南省重点研发与推广专项(科技攻关)项目(No.202102310493),河南省高校重点科研项目(No.19A360014),河南中医药大学博士科研基金项目(No.BSJJ2018-03)

Pathogenesis and treatment of tumors from the perspective of “transformation between healthy qi and pathogenic qi”*

Liu Yan1, Wu Yaosong1, Liu Jun1, Jiang Shihong2, Yang Tiezhu3, Ren Shanshan1, Chen Yulong1#   

  1. 1 Academy of Chinese Medical Sciences, Henan Provincial Key Laboratory of TCM Pattern and Prescription and Signal Transduction, Henan University of Chinese Medicine, Henan 450046;
    2 Graduate School, Henan University of Chinese Medicine, Henan 450046;
    3 Intensive Care Unit, Luoyang Orthopedic-Traumatological Hospital of Henan Province, Henan 450000
  • Received:2020-08-12 Online:2021-02-28 Published:2021-02-21
  • Contact: Prof. Chen Yulong, Ph. D., Doctoral Supervisor. Henan University of Chinese Medicine, No. 156 Jinshui Dong Road, Zhengdong New District, Zhengzhou 450046. E-mail: cyl72621@163.com
  • Supported by:
    National Natural Science Foundation of China (No. 81373535); Key R & D and Promotion Projects in Henan Province (No. 202102310493)

摘要: 通过阅读文献,对正邪相互转化的关系进行探讨,并在古今文献报道基础上指出肿瘤发生的关键因素——“恶气”是由正气失和化邪,邪气伏而化恶产生的。恶气弥散、熏蒸、充斥于机体组织内部,为肿瘤的形成提供了温床,与现代医学肿瘤微环境的概念有着异曲同工之妙。治疗当和其不和、疏利气机,使邪气复正、恶气消散。基于正邪转化角度阐释恶气产生机制,可更好地解释肿瘤的中医病因病机,指导临床治疗。将恶气理论与肿瘤微环境相接轨,可从细胞和分子水平上揭示恶气的内涵,为中医理论现代化研究提供思路和借鉴。

关键词: 正邪转化, 恶气, 纠偏复正, 肿瘤微环境

Abstract: Based on an analysis of “transformation between healthy qi and pathogenic qi” discussed in literatures, this paper points out that “e qi” (evil qi) seems to be the key factor of tumor occurrence. “E qi” is transformed from “pathogenic qi” lurked within the body, which is transformed from disharmonious healthy qi. “E qi” diffuses, fumigates, and fills the body, providing a ‘hotbed’ for tumor formation, which is similar to the concept of “tumor microenvironment” in modern medicine. In treatment of tumors, harmonize the discordant and promote qi movement, thus turning the pathogenic qi back to healthy qi to dissipate the ‘e qi’. Through interpreting the mechanism of ‘e qi’ based on the transformation of healthy qi and pathogenic qi, we can better explain the etiology and pathogenesis of tumors in TCM and guide clinical treatment. By correlating the theory of ‘e qi’ with the tumor microenvironment, we hope to reveal the connotation of ‘e qi’ in the cellular and molecular level, and provide references for the modernization of TCM theories.

Key words: transformation between healthy qi and pathogenic qi, e qi (evil qi), guiding pathogenic qi transforming to vital qi, tumor microenvironment

中图分类号: 

  • R273