主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2021, Vol. 44 ›› Issue (3): 215-220.doi: 10.3969/j.issn.1006-2157.2021.03.004

• 理论研究 • 上一篇    下一篇

从湿热理论辨析炎-癌转化机制*

田琳, 林翠丽, 孙月明, 柯晓, 黄铭涵#, 杨春波   

  1. 福建中医药大学附属第二人民医院 福建 350003
  • 收稿日期:2020-09-23 出版日期:2021-03-30 发布日期:2021-03-30
  • 通讯作者: #黄铭涵,男,硕士,副教授,副主任医师,硕士生导师,主要研究方向:湿热证的现代研究,E-mail:huangminghan2010@163.com
  • 作者简介:田琳,女,在读硕士生
  • 基金资助:
    *国家重点研发计划―中医药现代化研究重点专项项目(No.2018YFC1705402),国家自然科学基金项目(No.81673731)

Analysis of mechanism of inflammation-cancer transformation from damp-heat theory*

Tian Lin, Lin Cuili, Sun Yueming, Ke Xiao, Huang Minghan#, Yang Chunbo   

  1. The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fujian 350003, China
  • Received:2020-09-23 Online:2021-03-30 Published:2021-03-30
  • Contact: Associate Prof. Huang Minghan, Associate Chief Physician, Master Supervisor. The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine. No. 282 Wusi Road, Gulou District, Fuzhou 350003. E-mail: huangminghan2010@163.com
  • Supported by:
    National Key Research and Development Program of China -- Key Special Project of Research on Modernization of Traditional Chinese Medicine (No. 2018YFC1705402), National Natural Science Foundation of China (No. 81673731)

摘要: 湿热是临床上常见的致病因素,其致病具有黏腻、胶着的特点。炎症细胞与炎性介质构成了局部炎症微环境,肿瘤的形成、侵袭与转移以炎症微环境的持续存在为背景。湿热胶着难解的特性,提示湿热可能是炎症微环境的持续存在、难以治愈的重要因素。同时,湿热邪气成毒的过程与炎-癌转化的进程具有相似性,两者关系密切。肿瘤的主要致病物质如痰、瘀等,从本质上与湿、热同为一源,湿热作为始动因子参与了炎-癌转化的全过程。因此,在分析炎症微环境病因病机的基础上,本文从湿热理论深入探讨炎-癌转化的病理机制,可为临床辨治提供重要的理论依据。

关键词: 湿热理论, 炎-癌转化, 炎症微环境, 邪毒

Abstract: Damp-heat is a common pathogenic factor clinically, which is characterized by stickiness and greasiness. Inflammatory cells and inflammatory mediators constitute the local inflammatory microenvironment. The formation, invasion and metastasis of tumors are based on the persistent existence of inflammatory microenvironment. The characteristic stickiness of damp-heat suggests that it may be an important factor for the persistent and refractory inflammatory microenvironment. At the same time, the transformation into toxin from dampness-heat pathogenic qi is similar to the inflammation-cancer transformation, and there is a close relationship between them. The main pathogenic substances of tumor, such as phlegm and stasis, are essentially from the source of damp-heat, which participates in the whole process of the inflammation-cancer deterioration as an initiating factor. Therefore, on the basis of analyzing the etiology and pathogenesis of inflammatory microenvironment, this paper discusses in-depth the pathological mechanism of the inflammation-cancer transformation from the perspective of the damp-heat theory, providing important theoretical basis for clinical diagnosis and treatment.

Key words: damp-heat theory, inflammation-cancer transformation, inflammatory microenvironment, pathogenic toxin

中图分类号: 

  • R246.5