主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2021, Vol. 44 ›› Issue (3): 238-244.doi: 10.3969/j.issn.1006-2157.2021.03.008

• 中医体质 • 上一篇    下一篇

基于数据挖掘新型冠状病毒肺炎患者易感体质特征及用药规律*

陈子琴1, 陈佳1, 陈贝1, 张艳琳1, 王昆秀1, 罗志辉1, 顾骁磊1, 闫鹏2, 陈松1#   

  1. 1 湖北中医药大学针灸骨伤学院 针灸治未病湖北省协同创新中心 湖北 430061;
    2 荆州市第二人民医院
  • 收稿日期:2020-07-23 出版日期:2021-03-30 发布日期:2021-03-30
  • 通讯作者: #陈松,男,博士,副教授,硕士生导师,主要研究方向:针灸效应的基础及临床研究,E-mail:362573836@qq.com
  • 作者简介:陈子琴,女,在读硕士生
  • 基金资助:
    *第六批全国老中医药专家学术经验继承工作项目[No.国中医药人教发(2017)29号],国家中医药管理局岐黄工程项目[No.国中医药人教函(2018)284号],湖北省青年英才开发计划[No.鄂青联发(2020)1号],湖北中医名师工作室项目[No.鄂卫生计生通报(2018)15号],荆州市科技创新智库研究项目(No.JZCXZK202002)

Constitution characteristics and Chinese herbal prescription of patients susceptible to new coronavirus pneumonia based on data mining*

Chen Ziqin1, Chen Jia1, Chen Bei1, Zhang Yanlin1, Wang Kunxiu1, Luo Zhihui1, Gu Xiaolei1, Yan Peng2, Chen Song1#   

  1. 1 School of Acupuncture, Moxibustion, Orthopaedics and Traumatology, Hubei University of Chinese Medicine / Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion, Hubei 430061, China;
    2 The Second Hospital of Jingzhou, Hubei 430000, China
  • Received:2020-07-23 Online:2021-03-30 Published:2021-03-30
  • Contact: Associate Prof. Chen Song, Ph.D, Master's Supervisor. Hubei University of Chinese Medicine. No.188 Liangdao Street, Wuchang District, Wuhan 430061. E-mail:362573836@qq.com
  • Supported by:
    The Sixth Batch of National Senior TCM Experts' Academic Experience Inheritance Project (No. 2017- 29), National Administration of Traditional Chinese Medicine Qihuang Project (No. 2018-284), Hubei Provincial Young Talent Cultivation Plan (No. 2020-1), Hubei Prestigious TCM Teachers' Workshop Project (No.2018-15), Jingzhou Municipal Science and Technology Innovation Think Tank Research Project (No. JZCXZK202002)

摘要: 目的 分析新型冠状病毒肺炎(COVID-19)患者主要体质及最优中医药诊疗方案。方法 选取荆州市第二人民医院新冠肺炎病区患者,通过描述性分析新冠肺炎在院患者体质体征,并分析其有效中药处方,挖掘其核心用药。结果 COVID-19易感体质特征结果表明湿热质人群占比最高;COVID-19治疗期有效处方统计分析结果显示,本次新冠肺炎有效处方共涉及药物152味,其中频次最高为厚朴51次,使用剂量频次最高为15 g;药物四气五味以寒性(45.55%)、苦味(41.55%)最多,归经最多为肺经(26.28%),药物功效以化痰止咳平喘药(19.39%)最多;利用关联规则分析得出5味核心药物;利用聚类分析得到3类药物组合。结论 本次新冠肺炎湿热质为易感体质,治疗期用药原则为寒温并举、肺脾同调,治疗原则以祛湿化浊、通调气机为主,其核心处方由“达原饮”化裁而出,多以“三消”法加减运用。

关键词: COVID-19, 体质, 诊疗方案, 用药规律

Abstract: Objective To explore the predominant constitution of patients with novel coronavirus pneumonia (COVID-19) and the optimal Chinese medicine diagnosis and treatment plan. Methods Patients diagnosed with COVID-19 and treated in the Second Hospital of Jingzhou were included in the study. Descriptive analysis was made of the constitution survey of hospitalized patients with COVID-19, and statistical analysis was made of effective Chinese medicine prescriptions to mine their core herbs. Results The analysis of the constitutional characteristics of patients susceptible to COVID-19 showed that the proportion of those with wetness-heat constitution was the highest. The statistical analysis of effective prescriptions used during the treatment period of COVID-19 showed that all the effective prescriptions involved a total of 152 herbs, among which the most frequently used was Houpo (Magnolia Bark, Cortex Magnoliae Officinalis). It appeared in 51 prescriptions and the most frequently prescribed dose was 15 grams. In terms of the four properties and five flavors of the herbs, the most commonly used are herbs cold in nature (45.55%) and bitter in flavor (41.55%). In terms of meridian tropism, the most frequently entered meridian was the lung meridian (26.28%). In terms of indications, the herbs most commonly used were those to dissolve phlegm and relieve cough and panting (19.39%). Association rules analysis uncovered 5 core herbs and cluster analysis 3 herb combinations. Conclusion The constitution susceptible to the novel coronary pneumonia was the wetness-heat constitution. During the treatment period, both herbs cold and those warm in property were used to regulate both the lung and the spleen. The treatment principles included mainly these to dispel dampness and remove turbidity, and to free and regulate qi movement. The core herbs were derived from the classic formula Dayuan Yin (Membrane-source Decoction) modified to eliminatie internal disease causes, external causes and causes that are neither internal nor external.

Key words: COVID-19, body constitution, diagnosis and treatment plan, rules of prescribed herbs

中图分类号: 

  • R259