主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2021, Vol. 44 ›› Issue (4): 318-322.doi: 10.3969/j.issn.1006-2157.2021.04.006

• 中医体质 • 上一篇    下一篇

基于九种体质分类建立体质医学研究动物模型的思考*

王济1, 赵晓山2, 周玉美1, 王琦1#   

  1. 1 北京中医药大学国家中医体质与治未病研究院 北京 100029;
    2 南方医科大学中医药学院
  • 收稿日期:2020-05-24 发布日期:2021-04-29
  • 通讯作者: #王琦,男,教授,博士生导师,中国工程院院士,国医大师,主要研究方向:中医体质学,E-mail:wangqi710@126.com
  • 作者简介:王济,女,博士,教授,博士生导师
  • 基金资助:
    *国家自然科学基金面上项目(No.81973715)

Establishing animal constitution models for research on nine classification of TCM constitution*

Wang Ji1, Zhao Xiaoshan2, Zhou Yumei, Wang Qi1#   

  1. 1 National Institute of TCM Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
    2 School of Chinese Medicine,Southern Medical University
  • Received:2020-05-24 Published:2021-04-29
  • Contact: Prof.Wang Qi,Doctoral Supervisor, Beijing University of Chinese Medicine, No.11 Beisanhuan Donglu Road, Chaoyang Districy, Beijing 100029. E-mail:doctorwang2009@126.com
  • Supported by:
    Beijing Natural Science Foundation (No.81973715)

摘要: 中医体质学是近几年发展起来的新兴学科,但迄今未有系统建立体质动物模型的思路和方法。本文基于中医体质理论和“九种体质分类法”,提出体质动物模型构建需要注意几个问题:第一,需要符合中医体质理论;第二,需要考虑不同品系动物的体质特点;第三,需要针对不同体质的特点建立动物模型评价指标体系。并以啮齿类动物大鼠和小鼠为例,拟定了评价8种偏颇体质的观察指标。建立体质动物模型,可用于以下方面的研究:深入探究体质形成机理及其微观生物学特征;建立体质、疾病、证候的二维或三维模型,研究体质与疾病和证候的相关性;用于评价调体干预效果和调体方法的作用机制;用于研究毒性药物的体质易感性。

关键词: 九种体质分类, 体质, 动物模型

Abstract: Constitution (Tizhi) of traditional Chinese medicine (TCM) is a newly emerged subject developed in recent years, but there has been no established approaches to establishing such animal models. Based on the constitution theory and “nine classification of TCM constitution”, this paper puts forward several areas of focus in the construction of constitution animal models: firstly, the constitution theory of traditional Chinese medicine should be aligned; secondly, constitution characteristics of different animals should be taken into consideration; thirdly, the evaluation system of animal model according to the characteristics of different constitutions needs to be established. Taking rodents (rats and mice) as examples, the parameters for evaluating eight kinds of abnormal constitution were recommeded. The establishment of animal model of TCM constitution can be used for the following research: in-depth study of the rationale of TCM constitution and its micro biological characteristics; establishment of two-dimensional or three-dimensional model of constitution, disease and pattern in order to explore the correlation between constitution and disease and pattern; efficacy evaluation of the constitution-adjustment effect and mechanism of action; research on the constitution susceptibility to toxicity.

Key words: nine kinds of constitution classification, constitution, animal model

中图分类号: 

  • R229