主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2021, Vol. 44 ›› Issue (4): 350-357.doi: 10.3969/j.issn.1006-2157.2021.04.010

• 科技之窗 • 上一篇    下一篇

多时点动态观测原发性痛经寒凝血瘀证患者的脉图参数变化*

杨莹莹, 王天芳, 赵丽红#, 王燕平, 汤玲, 李宁, 李昕, 张文征   

  1. 北京中医药大学 北京 100029
  • 收稿日期:2020-05-25 发布日期:2021-04-29
  • 通讯作者: #赵丽红,博士,助理研究员,主要研究方向:中医诊法与辨证的客观化、规范化,E-mail:lihongzhaolhz@163.com
  • 作者简介:杨莹莹,女,在读博士生
  • 基金资助:
    *国家自然科学基金青年科学基金项目(No.81703984)

Variation of pulse parameters in patients of primary dysmenorrhea with the pattern of cold congelation and blood stasis based on multi-temporal dynamic observation*

Yang Yingying, Wang Tianfang, Zhao Lihong#, Wang Yanping, Tang Ling, Li Ning, Li Xin, Zhang Wenzheng   

  1. Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2020-05-25 Published:2021-04-29
  • Contact: A/Prof. Zhao Lihong, Beijing University of Chinese Medicine, Beijing 102488. E-mail: lihongzhaolhz@163.com.
  • Supported by:
    National Natural Science Foundation for Young Scientists of China (No. 81703984)
    Ethical review: Medical and Experimental Animal Ethics Committee, Beijing University of Chinese Medicine (No. 2017BZHYLL0505)

摘要: 目的 分析原发性痛经寒凝血瘀证患者脉图参数的动态变化及其与疼痛程度的相关性。方法 以原发性痛经寒凝血瘀证患者为原发性痛经组,健康者为对照组。在痛经典型发作时予以电针治疗,形成4个观测时点(T0:经前7~10 d,T1:经期痛经典型发作时,T2:针刺镇痛治疗30 min结束即刻,T3:针刺镇痛治疗结束后30 min)。运用道生DS01-C型脉象仪采集脉图参数,包括幅度(h)、时值(t)、宽度(w)、幅度比、时值比、宽度与时值比、心率(HR)等,并用视觉模拟评分(VAS)评定疼痛程度。统计方法采用重复测量的方差分析、Pearson积差相关系数、Spearman相关系数及均值、标准差等描述性分析的方法。结果 原发性痛经组纳入35例,对照组纳入32例。在疼痛程度的变化上,痛经发作前后,即4个时点的VAS比较结果,T1、T2、T3与T0比较均显著升高(P<0.05),T2、T3与T1比较均显著降低(P<0.05)。在脉图参数的变化上,痛经发作前后,即4个时点的脉图参数变化为:T1与T0比较,h2、h4、t1均显著升高(P<0.05);T2与T1比较,t5显著升高(P<0.05),h3/h1、w1/t、t1/t、t1HR均显著降低(P<0.05);T3与T2比较,h3/h1、w1/t、t1/t、t1均显著升高(P<0.05)。同一时点与对照组比较:T0时点,原发性痛经组h2、h4均显著低于对照组(P<0.05);T1时点,h3/h1、w1/t、t1、t1/t均显著高于对照组(P<0.05);T3时点,t1、t1/t均显著高于对照组(P<0.05)。在脉图参数与疼痛程度的相关性上,与VAS呈显著正相关的脉图参数是:h2、h3、h4、h3/h1、h4/h1、w1(P<0.05);与VAS呈显著负相关的脉图参数是:h5、h5/h1(P<0.05)。结论 原发性痛经寒凝血瘀证患者的脉图参数在痛经发作时较痛经发作前、缓解后及健康人群有一定程度改变,且其脉图参数的变化与疼痛程度有一定的相关性。

关键词: 脉图参数, 寒凝血瘀证, 原发性痛经

Abstract: Objective To analyze the dynamic changes of pulse parameters and their correlation with pain degree in patients of primary dysmenorrhea (PD) with the pattern of cold congelation and blood stasis. Methods PD patients with the pattern of cold coagulation and blood stasis were the PD group and healthy subjects were the control group. Electroacupuncture treatment was administered at the typical onset of dysmenorrhea. Four observation points (T0-7~10 days before menstruation, T1-menstrual dysmenorrhea typical attack, T2-after the acupuncture analgesia treatment for 30 min immediately,T3-30 min after acupuncture analgesia treatment) were made. Pulse parameters were collected by using DS01-C pulse imager, including amplitude(h), time(t), width(w), amplitude ratio, time-figure ratio, width-to-time-fiure ratio, heart rate(HR)and so on, and the Visual Analogue Score (VAS) was evaluated to assess pain severih. Repeated measurement variance analysis, Pearson correlation coefficient, Spearman correlation coefficient and the descriptive statistics including mean and standard deviation were used in statistical analysis. Results A total of 35 PD patients and 32 healthy controls were included. In terms of pain severity, VAS at T1,T2 and T3 were all significantly higher than T0 (P<0.05) while the scores at T2 and T3 were all significantly lower than T1 (P<0.05). As for pulse parameters, compared with T0,h2,h4,t1 of T1 all increased significantly (P<0.05); compared with T1, t5 of T2 increased significantly (P<0.05) and h3/h1,w1,w1/t,t1/t,t1,HR all decreased significantly (P<0.05); compared with T2, h3/h1,w1/t,t1/t,t1of T3 all increased significantly (P<0.05). Compared with healthy controls at the same time: the h2,h4 of the syndrome of cold congelation and blood stasis were all significantly lower than those in the healthy control (P<0.05), the h3/h1,w1/t、t1,t1/t were all significantly higher (P<0.05) at the T1 (P<0.05); the t1,t1/t were all significantly higher (P<0.05) at the T3 (P<0.05). In the correlation between pulse chart parameters and pain degree, the pulse chart parameters that were positively correlated with the VAS were: h2,h3,h4,h3/h1,h4/h1,w1(P<0.05); negatively correlated: h5,h5/h1(P<0.05).Conclusion Pulse parameters in patients of PD with the pattern of cold congelation and blood stasis seem to change after the onset of pain and compared to the healthy population. The changes of the pulse parameters correlated with the severity of pain

Key words: pulse parameters, syndrome of cold congelation and blood stasis, primary dysmenorrhea

中图分类号: 

  • R241.1