主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2021, Vol. 44 ›› Issue (4): 380-384.doi: 10.3969/j.issn.1006-2157.2021.04.014

• 临床研究 • 上一篇    

基于“脾应长夏恶湿”理论探讨长夏季节湿疹高发的生物学机制*

朱佩, 刘雷蕾, 孙一珂, 张海蓉, 马淑然#   

  1. 北京中医药大学中医学院 北京 102488
  • 收稿日期:2020-10-10 发布日期:2021-04-29
  • 通讯作者: #马淑然,女,博士,教授,博士生导师,主要研究方向:中医基础理论,E-mail:mashuran64@sina.com
  • 作者简介:朱佩,男,在读硕士生
  • 基金资助:
    *国家自然科学基金面上项目(No.81774162),北京中医药大学重点攻关项目(No.2020-JYB-ZDGG-016)

Exploring the underlying biological rationale for high incidence of eczema in late summer based on the theory of “spleen corresponding to late summer with aversion to dampness”*

Zhu Pei, Liu Leilei, Sun Yike, Zhang Hairong, Ma Shuran#   

  1. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China
  • Received:2020-10-10 Published:2021-04-29
  • Contact: Prof. Ma Shuran, Doctoral Supervisor. Beijing University of Chinese Medicine. Intersection of Yangguang Nandajie Street and Baiyang Donglu Road, Liangxiang Campus of Beijing University of Chinese Medicine, Liangxiang Higher Education Park, Fangshan District, Beijing 102488. E-mail: mashuran64@sina.com
  • Supported by:
    National Natural Science Foundation (No. 81774162)

摘要: 湿疹高发于长夏湿热环境中,其具体生物学机制尚未明确。联系环境变化对人的影响,从季节温湿变化阐释“脾应长夏”的理论,并根据现有科学成果提出支持本观点的物质基础与科学内涵,即“脾应长夏,喜燥恶湿”与褪黑素调控NF-κB介导的Th1/Th2免疫平衡之间具有密切联系,这是影响长夏季节湿疹高发的关键因素。本文从分析季节气候变化对人体生理病理产生重要影响、长夏季易发外内合邪与免疫相关的湿邪疾病、长夏季节湿疹高发的重要机制等多方面展开探讨,揭示长夏季节湿疹高发的生物学机制。提出“脾应长夏恶湿”理论与松果腺-褪黑素引起皮肤NF-κB-Th1/Th2调节链的季节性变化具有相关性:导致湿疹长夏季节高发的外界影响因子主要是温湿度季节性变化,中介物质是褪黑素,调节机制是皮肤中NF-κB介导的Th1/Th2细胞因子分泌的季节性变化。

关键词: 脾应长夏, 脾恶湿, 湿疹, 褪黑素, NF-κB通路

Abstract: Eczema tends to occur in damp heat environment in the season of late summer, and its specific biological rationale is not clear. This paper elaborates the theory of “the spleen corresponding to late summer” from the perspective of seasonal temperature and humidity changes on human being, and analyzes the existing scientific evidence. There is a close link between the theory of “the spleen corresponds to late summer, prefers dryness and dislikes dampness” and immune balance maintained by melatonin regulating NF- κB-mediated Th1/Th2, which is the key factor related to the high incidence of eczema in late summer. In order to reveal the biological rationale of the high incidence of eczema in late summer, this paper also analyzes the important influence of seasonal climate change on human physiology and pathology. Dampness related to external and internal pathogenic factors and immunity is more likely to develop in late summer, which is an important cause of eczema in late summer. It is proposed that the theory of “the spleen corresponding to late summer with aversion to dampness” is related to the seasonal changes of skin NF-κB-Th1/Th2 regulatory chain by pineal melatonin: the external factor leading to the high incidence of eczema in late summer is mainly due to the seasonal changes of temperature and humidity, and the mediator is melatonin. The regulatory mechanism is the seasonal change of Th1/Th2 cytokine secretion mediated by NF-κB in skin.

Key words: the spleen corresponding to late summer, the spleen dislikes dampness, eczema, melatonin, NF-κB pathway

中图分类号: 

  • R275.98