主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2021, Vol. 44 ›› Issue (6): 496-499.doi: 10.3969/j.issn.1006-2157.2021.06.003

• 理论研究 • 上一篇    下一篇

探讨子午流注学说与胶质淋巴系统调整睡眠节律防治阿尔茨海默病的作用*

刁华琼1, 丁海月1, 李小黎1#, 陈琳1, 魏丹1, 张婧1, 李倩倩2, 鲁丽华1, 张乃文1, 李梦媛1   

  1. 1 北京中医药大学第三附属医院脑病科 北京 100029;
    2 首都医科大学附属北京中医医院针灸科
  • 收稿日期:2020-11-26 出版日期:2021-06-30 发布日期:2021-06-25
  • 通讯作者: #李小黎,男,博士,教授,博士生导师,主要研究方向:中医药防治脑病,E-mail:tigerlxl2002@163.com
  • 作者简介:刁华琼,女,在读硕士生
  • 基金资助:
    *国家自然科学基金面上项目(No.81673930)

Effects of the glymphatic system and the midnight-noon ebb-flow theory on adjustment of the circadian rhythm and the prevention and treatment of Alzheimer’s disease*

Diao Huaqiong1, Ding Haiyue1, Li Xiaoli1#, Chen Lin1, Wei Dan1, Zhang Jing1, Li Qianqian2, Lu Lihua1, Zhang Naiwen1, Li Mengyuan1   

  1. 1 Department of Encephalopathy, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China;
    2 Department of Acupuncture and Moxibustion, Beijing Hospital of TCM Affiliated to Capital Medical University, Beijing 100016, China
  • Received:2020-11-26 Online:2021-06-30 Published:2021-06-25
  • Contact: Prof. Li Xiaoli, Ph.D., Doctoral Supervisor. Beijing University of Chinese Medicine Third Affiliated Hospital. No.5 Xiaoguan Street, Andingmenwai, Chaoyang District, Beijing 100029. E-mail:tigerlxl2002@163.com
  • Supported by:
    National Natural Science Foundation of China (No. 81673930)

摘要: 子午流注学说基于“天人相应”整体观,认为人体气血随不同时辰阴阳消长而循序流注于十二经脉,与睡眠节律密切相关。胶质淋巴系统是能清除脑内代谢产物的交换流动系统,对阿尔茨海默病的进展有一定影响。通过分析子午流注学说与胶质淋巴系统防治阿尔茨海默病的研究成果,发现睡眠节律是二者影响认知功能的共同作用途径,故提出“运用子午流注学说调节睡眠节律,提高胶质淋巴系统的流动峰值,促进脑内β淀粉样蛋白代谢,进而减轻认知功能损害”的构思,以期拓展阿尔茨海默病的中医药防治思路。

关键词: 胶质淋巴系统, 子午流注, 睡眠节律, 阿尔茨海默病, β淀粉样蛋白

Abstract: Based on the holistic view of “correspondence between human beings and nature”, the midnight-noon ebb-flow theory holds that qi and blood flow in the twelve meridians in sequence with the waxing and waning of yin and yang at different hours of the day, which is correlative with the circadian rhythm. Glymphatic system, a flowing exchange system, which clears intracephalic metabolites, has an effect on the progression of Alzheimer’s disease. This article analyzes the application of the midnight-noon ebb-flow theory and lymphatic system in the prevention and treatment of Alzheimer’s disease and discovers that both affect the cognitive function through the circadian rhythm. Therefore, it is argued that “the midnight-noon ebb-flow theory may be used to adjust the circadian rhythm to improve the peak flow of the lymphatic system, promote β-amyloid metabolism and alleviate cognitive disorder”, which could provide reference for the prevention and treatment of Alzheimer’s disease with traditional Chinese medicine.

Key words: glymphatic system, midnight-noon ebb-flow, circadian rhythm, Alzheimer’s disease, β-amyloid

中图分类号: 

  • R224.3