主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2021, Vol. 44 ›› Issue (9): 812-817.doi: 10.3969/j.issn.1006-2157.2021.09.008

• 理论研究 • 上一篇    下一篇

脾虚浊毒论*

孙建慧1, , 杨倩1, , 张纨2, 王志坤1, 刘阳1, 王斌1, 刘启泉1#   

  1. 1 河北中医学院第一附属医院 河北 050011;
    2 中国人民大学医院
  • 收稿日期:2021-03-25 出版日期:2021-09-30 发布日期:2021-10-08
  • 通讯作者: # 刘启泉,男,主任医师,教授,博士生导师,主要研究方向: 脾胃病理论与实验研究,E-mail:liuqq56@163.com
  • 作者简介:孙建慧,女,在读博士生
  • 基金资助:
    *国家中医临床研究基地业务建设项目(No.国中医药科技函2018-131号),国家中医药管理局全国名中医传承工作室建设项目(No.国中医药办人教函2018-119号),河北中医学院2021年研究生创新资助立项项目(No.XCXZZBS2021011)

The theory of turbidity-toxin induced by spleen deficiency*

Sun Jianhui1, Yang Qian1, Zhang Wan2, Wang Zhikun1, Liu Yang1, Wang Bin1, Liu Qiquan1#   

  1. 1 The First Affiliated Hospital of Hebei University of Chinese Medicine, Hebei 050011, China;
    2 Hospital of Renmin University of China, Beijing 100872, China
  • Received:2021-03-25 Online:2021-09-30 Published:2021-10-08
  • Contact: Prof. Liu Qiquan, Bachelor, Chief Physician, Doctoral Supervisor. The First Affiliated Hospital of Hebei University of Chinese Medicine. No. 389 East Zhongshan Road, Chang'an District, Shijiazhuang, Hebei 050011. E-mail: liuqq56@163.com
  • Supported by:
    Special Research Project for Clinical Capacity Building of National TCM Clinical Research Base (No. [2018]131), Development Project of Workshop for Inheritance from National Prestigious & Senior Traditional Chinese Medicine Experts of National Administration of Traditional Chinese Medicine (No. [2018]119)

摘要: 浊毒理论是国医大师李佃贵教授提出的创新性理论。目前,浊毒理论的研究重点在于浊毒的致病特性和因浊毒所演发的病理改变,对于浊毒形成的条件性及内生性尚未形成系统化认识。文章立足于脏腑观,以脾脏的生理功能、病理改变为基,以现代研究热点免疫功能、人体微生态为切入点,从“脾虚-肠道菌群失调/免疫功能障碍-浊毒”动态病机演变探讨浊毒生成之源,阐明浊毒产生及浊毒致病的条件性,归纳脾虚生浊成毒的致病特性,完善浊毒的病机内涵。脾虚浊毒论是浊毒理论的补充与完善,为浊毒理论的进一步研究提供新思路。

关键词: 浊毒理论, 脾虚, 肠道菌群, 免疫功能, 浊毒

Abstract: The turbidity-toxin theory is an innovative theory put forward by Professor Li Diangui, a master of traditional Chinese medicine. At present, the research of turbidity-toxin theory mainly focuses on the pathogenic characteristics of turbidity-toxin and the pathological changes caused by turbidity-toxin. However, there is no systematic understanding of the condition and endogenous nature of the formation of turbidity-toxin. Based on the theory of the zang-fu organs and the physiological function and pathological changes of spleen, and in view of the hotspots of immune function and human micro-ecology in modern research, this paper discusses the origin of turbidity-toxin from the perspective of dynamic pathogenesis evolution from spleen deficiency to intestinal flora imbalance or immune dysfunction and to turbidity-toxin, clarifies the conditions for the formation and pathogenicity of turbidity-toxin, and summarizes the pathogenic characteristics of spleen deficiency induced turbidity-toxin, improving the understanding of the pathogenesis of turbidity-toxin. The theory of turbidity-toxin induced by spleen deficiency complements and develops the turbidity-toxin theory, providing new ideas for further study of the latter.

Key words: theory of turbidity-toxin, spleen deficiency, intestinal flora, immune function, turbidity-toxin

中图分类号: 

  • R223