主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2021, Vol. 44 ›› Issue (9): 860-864.doi: 10.3969/j.issn.1006-2157.2021.09.015

• 临床研究 • 上一篇    

基于线粒体能量代谢障碍探讨从脾论治“双心疾病”的机制*

杜敏1, 陶丽宇2, 冯骁腾1, 沈虹1, 刘萍1#   

  1. 1 上海中医药大学附属龙华医院 上海 200032;
    2 上海中医药大学附属曙光医院
  • 收稿日期:2021-04-13 出版日期:2021-09-30 发布日期:2021-10-08
  • 通讯作者: #刘萍,女,博士,教授,主任医师,博士生导师,主要研究方向:中西医结合防治心血管疾病,E-mail:liuping0207@126.com
  • 作者简介:杜敏,女,在读博士生
  • 基金资助:
    *上海市科学技术委员会科研计划项目(No.18401900200),上海市浦东新区卫生和计划生育委员会卫生计生科研项目(No.PW2018D- 11),上海市卫生健康委员会中医药科研项目(No.2020LQ013)

Discussion on the mechanism of treating “psychocardiological disease” from the perspective of spleen based on mitochondrial energy metabolism disorder*

Du Min1, Tao Liyu2, Feng Xiaoteng1, Shen Hong1, Liu Ping1#   

  1. 1 Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;
    2 Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2021-04-13 Online:2021-09-30 Published:2021-10-08
  • Contact: Prof. Liu Ping, Ph.D., Chief Physician, Doctoral Supervisor. Long Hua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. No. 725 South Wanping Road, Shanghai 200032. E-Mail: liuping0207@126.com
  • Supported by:
    Scientific Research Project of Science and Technology Commission of Shanghai Municipality (No. 18401900200), Health and Family Planning Scientific Research Project of Shanghai Pudong New Area Health and Family Planning Commission (No. PW2018D-11), Research Project of Traditional Chinese Medicine of Shanghai Municipal Health Commission (No. 2020LQ013)

摘要: “双心疾病”是心病科的常见病、多发病,脾失健运是其重要发病机制。近年来研究发现,线粒体能量代谢障碍与双心疾病发病具有一定相关性,中医“脾”与线粒体的功能特性具有许多共通之处,脾虚的本质是线粒体功能障碍,临床中采用健脾益气、醒脾化湿能有效改善双心疾病症状、缓解精神障碍,并改善线粒体功能。本文将基于线粒体能量代谢障碍,探讨从脾论治双心疾病的机理,为临床“双心疾病”治疗提供一定的思路。

关键词: 双心疾病, 脾, 线粒体, 能量代谢障碍, 从脾论治

Abstract: “Psychocardiological disease” is a common and frequently-occurring disease in the department of cardiology with dysfunction of spleen in transportation as the important pathogenesis. In recent years, a large number of studies have found that mitochondrial energy metabolism disorders are related to the occurrence of psychocardiological disease. The characteristics of the function of “spleen” and mitochondria are similar to a large extent. The essence of spleen deficiency is mitochondrial dysfunction. In clinical practice, invigorating the spleen and replenishing qi, and activating the spleen and draining dampness can significantly improve the symptoms of psychocardiological disease and alleviate mental disorders while improving mitochondrial function. This paper will explore the mechanism of treating psychocardiological disease from the perspective of spleen based on energy metabolism disorder of mitochondria so as to provide reference for the clinical treatment of the psychocardiological disease.

Key words: psychocardiological disease, spleen, mitochondria, energy metabolism disorder, treatment from the perspective of spleen

中图分类号: 

  • R256.2