主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2014, Vol. 37 ›› Issue (2): 126-129.doi: 10.3969/j.issn.1006-2157.2014.02.013

• 中药制剂 • 上一篇    下一篇

响应面设计法优化橄榄泡腾片的制备及其抗氧化作用的研究

邓迪, 翁梓聪, 谢丽瑜, 黄裕茵, 马燕   

  1. 广州中医药大学中药学院 广东 510006
  • 收稿日期:2013-08-09 出版日期:2014-02-28 发布日期:2014-02-28
  • 通讯作者: 马燕,女,博士,副教授,硕士生导师,E-mail:mygzucm@163.com
  • 作者简介:邓迪,男,在读本科生
  • 基金资助:
    广州中医药大学国家级大学生创新创业实践项目训练计划(No.201210572053)

Preparation of Olive Effervescent Tablets optimized by response surface methodology and its antioxidant effect

DENG Di, WENG Zi-cong, XIE Li-yu, HUANG Yu-yin, MA Yan   

  1. School of Chinese Pharmacy, Guangzhou University of Chinese Medicine, Guangdong 510006
  • Received:2013-08-09 Online:2014-02-28 Published:2014-02-28

摘要: 目的 制备口感风味良好,具有抗氧化作用的橄榄泡腾片。方法 采用Box-Behnken响应面设计法优化橄榄泡腾片制剂处方;采用Folin-Ciocalteu法测定成品中酚类物质的含量,以清除1,1-二苯基-2-苦苯肼(DPPH)自由基的能力验证其抗氧化作用。结果 确定的最优处方主要成分为:原料药35.1%,甘露醇27.9%,酒石酸19.5%,碳酸氢钠15.6%,乙醇1.6%,PEG 6000 0.4%,每片(0.38 g)含酚类物质54.09 mg,其清除DPPH自由基能力优于维生素C。结论 制备出具有抗氧化保健功能且口感良好的橄榄泡腾片,其抗氧化功能具有明确的市场定位。

关键词: 橄榄, 泡腾片, 响应面设计法, 1, 1-二苯基-2-苦苯肼

Abstract: Objective To prepare Olive Effervescent Tablets with a good flavor and antioxidant effect. Methods The prescription of Olive Effervescent Tablets was optimized by using Box-Behnken response surface methodology. The content of phenolics was detected by using Folin-Ciocalteu assay, and antioxidant effect of which were verified by detecting scavenging activity of diphenyl picrylhydrazyl (DPPH). Results The main components in optimum prescription were as follows: active pharmaceutical ingredients accounted for 35.1%, mannitol, 27.9%, tartaric acid, 19.5%, sodium bicarbonate, 15.6%, ethyl alcohol, 1.6%, and PEG 6000 0.4%. Phenolics accounted for 54.09 mg per tablet (0.38 g). The scavenging activity of DPPH of Olive Effervescent Tablets was superior to Vitamin C. Conclusion Prepared Olive Effervescent Tablets has a good flavor and antioxidant effects, and its antioxidant effect has clear market positioning.

Key words: olive(Canavium album Raeuseh), effervescent tablets, response surface methodology, 1,1-diphenyl picrylhydrazyl

中图分类号: 

  • R283.6