主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2017, Vol. 40 ›› Issue (5): 436-441.doi: 10.3969/j.issn.1006-2157.2017.05.013

• 临床研究 • 上一篇    

平颤益髓方治疗帕金森病髓海不足证合并轻度认知功能损伤的疗效研究*

陆征宇1, 陆玲丹1, 朱冬雨1, 徐强2, 陈洁1, 赵虹1#   

  1. 1 上海中医药大学附属岳阳中西医结合医院神经内科 上海 200437;
    2 山东省泰安市中医医院重症监护室
  • 收稿日期:2016-11-16 出版日期:2017-05-30 发布日期:2017-05-30
  • 通讯作者: 赵虹,女,主任医师,硕士生导师,主要研究方向:中西医结合神经病学,E-mail:drzhaohong@126.com
  • 作者简介:陆征宇,男,博士,副主任医师
  • 基金资助:
    *国家自然科学基金项目(No. 81503551), 上海市科委医学引导类科技项目(No. 15401930200), 上海市自然科学基金项目(No. 15ZR1442300), 上海市治未病预防保健服务体系建设项目(No. ZY3-FWMS-1-1001-KYJS-13), 上海市进一步加快中医药事业发展三年行动计划项目(No. ZY3-RCPY-3-1030), 上海市人才发展资金项目(No. 201456)

Clinical effect of Pingchan Yisui Fang on Parkinson’s disease complicated with mild cognitive impairment of type of marrow sea deficiency*

LU Zhengyu1, LU Lingdan1, ZHU Dongyu1, XU Qiang2, CHEN Jie1, ZHAO Hong1#   

  1. 1 Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;
    2 ICU, Tai’an Hospital of Traditional Chinese Medicine, Shandong 271000,China
  • Received:2016-11-16 Online:2017-05-30 Published:2017-05-30
  • Supported by:
    Project sponsored by National Natural Science Foundation (No. 81503551), Medical Pilot Science and Technology Project of Shanghai Science and Technology Commission (No. 15401930200), Natural Science Foundation of Shanghai (No. 15ZR1442300), Construction Project of Preventive Treatment of Diseases and Health Care Service System on in Shanghai (No. ZY3-FWMS-1-1001-KYJS-13), Shanghai 3-Year Action Plan on Further Accelerating Development of TCM (No. ZY3-RCPY-3-1030), Shanghai Municipal Fund for Talent Development (No. 201456)

摘要: 目的 观察平颤益髓方治疗帕金森病髓海不足证合并轻度认知功能损伤(PD-MCI)的临床疗效。方法 将103例PD-MCI患者随机分为对照组与中药组,对照组给予西医基础治疗,中药组在西医基础治疗上加用平颤益髓方,连续治疗36周。分别在治疗前后进行帕金森病统一评分量表(UPDRS)、蒙特利尔认知评估量表(MoCA)、简易智能精神状态检查量表(MMSE)疗效评估。结果 治疗后,中药组UPDRS评分显著低于对照组(P<0.05),MoCA及MMSE评分显著高于对照组(P<0.01),MoCA量表的注意力、抽象能力、延迟回忆、定向力等因子评分以及MMSE量表的定向能力、记忆能力、注意力、回忆能力等因子评分显著高于对照组(P<0.05或P<0.01)。结论 西药基础治疗加用平颤益髓方能有效改善PD-MCI患者的运动症状及认知功能障碍。

关键词: 帕金森病, 轻度认知功能损伤, 中西医结合治疗, 平颤益髓方

Abstract: Objective To observe the clinical efficacy of Pingchan Yisui Fang on Parkinson’s disease complicated with mild cognitive impairment (PD-MCI) of type of marrow sea deficiency. Methods The patients with Parkinson’s disease complicated with mild cognitive impairment (PD-MCI) of type of marrow sea deficiency (n=103) were randomly divided into control group and Chinese medicine group (CM group), and control group was given basic treatment of Western medicine and CM group was additionally given Pingchan Yisui Fang for 36 weeks. The curative effect was reviewed by using Unified Parkinson’s Disease Rating Scale (UPDRS), Montreal Cognitive Assessment Scale (MoCA) and Minimum Mental State Examination (MMSE) before and after treatment. Results The scores of UPDRS were significantly lower (P<0.05), and scores of MoCA and MMSE were significantly higher (P<0.01) in CM group than those in control group after treatment. The factor scores of attention, abstract ability, delayed recall and orientation in MoCA, and orientation, memory ability, attention and recall ability in MMSE were significantly higher in CM group than those in control group (P<0.05 or P<0.01) after treatment. Conclusion Pingchan Yisui Fang can effectively relieve motor symptoms and cognitive disorder on the base of standardized treatment of Western medicine in patients with PD-MCI.

Key words: Parkinson’s disease, mild cognitive impairment, treatment integrated Chinese and Western medicine, Pingchan Yisui Fang

中图分类号: 

  • R256.23