主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

北京中医药大学学报 ›› 2017, Vol. 40 ›› Issue (7): 603-606.doi: 10.3969/j.issn.1006-2157.2017.07.013

• 临床研究 • 上一篇    下一篇

解毒活血方对经皮冠状动脉介入术患者围术期心肌损伤的影响

王新东1,2, 祁晓霞3#, 黄丹1,2, 张苏洁1,2, 高昕1,2, 张一炎1,2   

  1. 1 南京中医药大学附属中西医结合医院心血管科 江苏 210028;
    2 江苏省中医药研究院;
    3 南京中医药大学
  • 收稿日期:2017-02-22 出版日期:2017-07-10 发布日期:2017-07-10
  • 通讯作者: 祁晓霞,女,硕士,副主任医师,主要研究方向:冠心病的中西医结合防治,E-mail:qxx@ 188.com
  • 作者简介:王新东,男,在读博士生,副主任医师
  • 基金资助:
    国家自然科学基金资助项目(No.81403386),江苏省自然科学基金资助项目(No.BK20161078),中国中医科学院江苏分院资助项目(No.JSBY1316)

Influence of Jiedu Huoxue Fang on perioperative myocardial injury in patients undergone percutaneous coronary intervention*

WANG Xindong1,2, QI Xiaoxia3#, HUANG Dan1,2, ZHANG Sujie1,2, GAO Xin1,2, ZHANG Yiyan1,2   

  1. 1 Department of Cardiovascular Diseases, Hospital of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu 210028, China;
    2 Jiangsu Academy of Traditional Chinese Medicine, Jiangsu 210028, China;
    3 Nanjing University of Chinese Medicine, Jiangsu 210023, China
  • Received:2017-02-22 Online:2017-07-10 Published:2017-07-10
  • Supported by:
    National Natural Science Foundation of China (No. 81403386), Natural Science Foundation of Jiangsu Province (No. BK20161078), Jiangsu Branch of China Academy of Chinese Medical Sciences (No. JSBY1316)

摘要: 目的 观察解毒活血配方颗粒冲服对经皮冠状动脉介入术(PCI)患者的围术期心肌损伤的影响。方法 160例接受PCI术的心绞痛患者随机分为解毒活血组(n=84)和对照组(n=76),解毒活血组给予常规治疗同时术前第7天给予解毒活血配方颗粒冲服,每日1剂。对照组给予基础药物治疗。测定PCI术前及术后12 h、24 h的血清肌酸激酶同工酶(CK-MB)和肌钙蛋白I(cTn I)浓度。结果 解毒活血组PCI术后12 h、24 h cTn I和CK-MB水平均显著低于对照组(P=0.003 8,P=0.027 6;P=0.001 2,P=0.002 7)。解毒活血组患者术后cTn I和CK-MB升高大于正常值3倍者构成比均显著低于对照组(P=0.008 2,P=0.007 6)。结论 术前给予解毒活血配方颗粒对于PCI围手术期病人的心肌损伤具有一定的保护作用。

关键词: 解毒活血, 经皮冠状动脉介入术, 围术期心肌损伤

Abstract: Objective To observe the influence of Jiedu Huoxue Fang (Detoxification and Blood-Activating Granules) on perioperative myocardial injury in patients undergone percutaneous coronary intervention (PCI). Methods The patients with angina pectoris received PCI (n=160) were randomly divided into Jiedu Huoxue Fang group (n=84) and control group (n=76). The Jiedu Huoxue Fang group was given routine treatment and Jiedu Huoxue Fang (1 dose/d) 7 d before PCI. The control group was treated with basic drugs. The levels of serum creatine kinase-M B isoenzyme (CK-MB) and cardiac troponin I (cTn I) were detected before and 12 h and 24 h after PCI. Results The levels of serum cTn I and CK-MB were significantly lower in Jiedu Huoxue Fang group than those in control group 12 h after PCI (P=0.003 8, P=0.027 6) and 24 h after PCI (P=0.001 2, P=0.002 7). The constituent ratio of patients with cTn I and CK-MB increasing by 3 times more than normal value was significantly lower in Jiedu Huoxue Fang group than that in control group (P=0.008 2,P=0.007 6). Conclusion Jiedu Huoxue Fang administrated before PCI has a certain preventive effect on perioperative myocardial damage.

Key words: detoxification and blood-activating, percutaneous coronary intervention, perioperative myocardial damage

中图分类号: 

  • R259.44