主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (1): 33-38.doi: 10.3969/j.issn.1006-2157.2014.01.008

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Influences of antagonism combinations of Gancao (Radix Glycyrrhizae) and Gansui (Radix Euphordiae Kansui) in modified Gansui Banxia Tang on hepatic and renal functions in rats with ascites

LIU Hai-yan1, ZHONG Gan-sheng1, LIU Jia1, WANG Xi2, LI Yi-wen1, LIU Yun-xiang1, GAO Yuan1, OU Li-na1   

  1. 1 School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029;
    2 Hebei University of Traditional Chinese Medicine
  • Received:2013-06-19 Online:2014-01-30 Published:2014-01-30

Abstract: Objective To discuss whether the efficacy or tocicity being correlated to the antagonism combinations of Gancao (Radix Glycyrrhizae) and Gansui (Radix Euphordiae Kansui) in modified Gansui Banxia Tang through observing the influences of the antagonism combinations on hepatic and renal functions in rats with malignant ascites. Methods Wistar rats were divided, according to weight, into blank group, model group, furosemide group, whole formula group of Gansui Banxia Tang (whole formula group), non-Gansui group, non-Gancao group and non-Gansui non-Gancao group. Besides of normal feeding, furosemide group, whole formula group, non-Gansui group, non-Gancao group and non-Gansui non-Gancao group were intragastrically given corresponding medicinal (10 mL/kg), and blank group and model group were orally given distilled water (10 mL/kg). After 9 d, all rats were fasted except of water for 12 h. The blood samples were collected and centrifugated for detecting relative indexes of hepatic and renal functions. Results Compared with model group, AST/ALT decreased (P<0.01), ALP increased (P<0.05), total protein (TP) increased (P<0.05), ratio of albumin (ALB) to A/G increased (P<0.05 or P<0.01), blood urea nitrogen (BUN) decreased (P<0.05) and creatinine (CRE) decreased (P<0.05) in whole formula group. Compared with whole formula group, AST/ALT increased (P<0.05 or P<0.01) and ratio of ALB to A/G decreased (P<0.05 or P<0.01) in non-Gansui group, non-Gancao group and non-Gansui non-Gancao group. Conclusion In whole formula group and the groups without one or two antagonism medicinal, there is no obvious toxicity observed for hepatic and renal functions, while the medicinal efficacy is higher in whole formula group. Antagonism combinations may have effect of improving medicinal efficacy.

Key words: dose of clinical application, Gansui Banxia Tang, antagonism combinations of Gancao (Radix Glycyrrhizae) and Gansui (Radix Euphordiae Kansui), ascites, hepatic and renal functions, rats

CLC Number: 

  • R285.5