主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (1): 68-70.doi: 10.3969/j.issn.1006-2157.2014.01.015

Previous Articles    

Syndrome factors of multiple sclerosis in 500 patients

FAN Yong-ping, WU Wei   

  1. Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050
  • Received:2013-07-25 Online:2014-01-30 Published:2014-01-30

Abstract: Objective To study on establishing quantized criteria for TCM syndromes of multiple sclerosis. Methods The patients (n=500) were chosen according to TCM four examinations. The combinations of TCM symptom entries and combinations of TCM syndrome factors were extracted by using entropy-based complex system partition method, and contribution degrees of all symptom entries to corresponding combinations of TCM syndrome factors were determined by using multiple regression method. The diagnostic thresholds were established with ROC curves of diagnostic test. Results There were 6 combinations of TCM syndrome factors got from entropy clustering results, and they were liver-kidney yin deficiency, spleen-kidney yang deficiency, spleen qi deficiency, blood stasis, phlegm dampness and phlegm heat and engendering wind. Different symptom entries had different contribution degrees to corresponding combinations of TCM syndrome factors, and all combinations of TCM syndrome factors had different diagnostic thresholds, which had higher sensitivity and specificity through the retrospective verification taken experts’syndrome differentiation as the gold standard. Conclusion The Syndrome Diagnostic Scale of Multiple Sclerosis established by applying various statistical methods has good diagnostic performance and conforms to clinical demands.

Key words: multiple sclerosis, syndrome factors, data mining, scale

CLC Number: 

  • R277.744.5+1