主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (4): 280-284.doi: 10.3969/j.issn.1006-2157.2014.01.016

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Regulation of FAH gene and PTGS2 gene by acupoint selection on the same meridian for controlling migraine

HUANG Yin-lan1, WAN Ming-yu2, LIANG Xi-sen1, LIANG Fan-rong3   

  1. 1 Ningxia Medicine University, Ningxia 750003;
    2 Dongfang College, Beijing University of Chinese Medicine;
    3 Chengdu University of Traditional Chinese Medicine
  • Received:2013-06-24 Online:2014-04-30 Published:2014-04-30

Abstract: Objective To observe the difference in the expressions of FAH gene and PTGS2 gene regulated by acupoint selection on the same meridian in patients with migraine. Methods The patients (n=20) were diagnosed as migraine (type of hyperactivity of liver-yang), and then divided into acupoint group and non-acupoint group (each n=10). The acupoint group was given needling in Jiaosun (TE20), Waiguan (TE15), Yanglingquan (GB34) and Qiuxu (GB40), and non-acupoint group was given needling in 4 non-acupoints once a day for 10 times. The samples of peripheral vein blood were collected from all patients before and after treatment, and genetic expression profiles were obtained by using gene chip technology. After Gene Ontology (GO) analysis, the profiles were reviewed with Visual Analogue Scale (VAS) before and after treatment in two groups. Results The expressions of FAH gene and PTGS2 gene decreased significantly in all samples in acupoint group (FAH: P<0.05, PTGS2: P<0.05 after GO analysis), while there were no expressions of these two genes observed in non-acupoint group. The results of VAS review showed that there was no difference between two groups before treatment (P>0.05). In acupoint group, there was difference before and after treatment (P<0.05), and there was difference after treatment and after follow-up (P<0.05). In non-acupoint group, there was difference before and after treatment (P<0.05), and there was no difference after treatment and after follow-up (P>0.05). The comparison in D-value in two groups before and after treatment showed difference (P<0.05). The immediate curative effect and long-term curative effect were more significant in acupoint group than those in non-acupoint group. Conclusion Acupoint selection on the same meridian has curative effect on migraine without aura (type of hyperactivity of liver-yang) and one of mechanisms may related to regulating FAH gene and PTGS2 gene.

Key words: FAH gene, PTGS2 gene, acupoint selection on the same meridian, migraine without aura, meridian acupoint effect

CLC Number: 

  • R245