主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (2): 121-125.doi: 10.3969/j.issn.1006-2157.2014.02.012

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Kinetic model applicability of total flavonoids extracted from Gusuibu (Rhizoma Drynariae) by using water decoction method

ZHANG Jin1, LI Xin-cun2, GE Liang1,3, QI Juan-juan1, CAO Sa-li1, ZHAG Hui1, DANG Xiao-fang1, YANG Bo-di1, NI Jian1   

  1. 1 School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102;
    2 Pharmaceutical Department, First Affiliated Hospital of Zhengzhou University;
    3 School of Chinese Pharmacy, Xinjiang Medical University
  • Received:2013-07-25 Online:2014-02-28 Published:2014-02-28

Abstract: Objective To study the extraction kinetic mechanism and fit out extraction kinetics equation during water decocting taken total flavonoids extracted from Gusuibu (Rhizoma Drynariae) as determination index. Methods At first, the existing model in laboratory was simplified and deduced, and then the concentration of extracting solution with different extraction time (t) and solvent loading (M) was detected by using ultraviolet spectrophotometry according to the parameters and characteristics of the model. The parameters of equation were deduced based on Fick’s scattering laws, and the results were substituted into mathematic model for equation fitting. Results The natural logarithm of concentration of total flavonoids had good linear relationship as t and M were redoubled. According to the slopes and intercepts of linear regression equation under different conditions, the calculated results as follows: n=-0.323 54, a=27.730 05 and f1=0.023 019. A equation was established with accurate detecting results and standard deviation was controlled within industrial tolerance interval. Conclusion The established model can be applied to and descript well the kinetic extraction course of Gusuibu (Rhizoma Drynariae).

Key words: Gusuibu (Rhizoma Drynariae), extraction kinetic model, model simplification, total flavonoids

CLC Number: 

  • R283.1