主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (3): 160-164.doi: 10.3969/j.issn.1006-2157.2014.03.004

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Influences of Qishen Yiqi Gutta Pills on heart function and ventricular remodeling in minipigs with heart failure induced by Ameroid constrictor

QIU Qi1, WANG Wei2, YANG Ke-xu1, SUO Wei1, WANG Yong2, LI Chun2, CHUO Wen-jing2, LIN Yang1   

  1. 1 Beijing University of Chinese Medicine,Beijing 100029;
    2 Beijing Anzhen Hospital, Capital University of Medical Sciences
  • Received:2013-11-18 Online:2014-03-30 Published:2014-03-30

Abstract: Objective To observe the influences of Qishen Yiqi Gutta Pills on heart function and ventricular remodeling in minipigs with heart failure induced by Ameroid constrictor. Methods The model of chronic myocardial ischemic heart failure was established in Bama minipigs (n=22) through putting Ameroid constrictor in left anterior descending coronary artery, and then divided into model group, digoxin group and Qishen Yiqi Gutta Pills group (Qishen group, each n=6) and other 4 included into sham-operation group. On the 4th week after the operation, digoxin group was given digoxin once a day (0.0125 mg/kg once) and Qishen group was given Qishen Yiqi Gutta Pills 3 times a day (0.025 g/kg once) for 8 weeks. The heart function was detected by using echocardiogram in all groups before medication and on the 2nd week, 4th week and 8th week after medication. The pathological changes of myocardial tissue were observed on the 8th week after medication. Results The results of echocardiogram showed that LVEF decreased significantly (P<0.01) in model group before medication. LVDV, LVSV and EF% were significantly improved (P<0.05) in digoxin group 2 weeks after medication, and those were significantly improved (P<0.05 or P<0.01) in Qishen group 4 weeks after medication. HE staining showed that abnormal structure of myocardial cells and a lot of inflammatory cell infiltration in model group, which were relieved in Qishen group. Masson staining showed that diffuse distribution of myocardial collagen in model group, and dendritic distribution in Qishen group. The content of myocardial collagen was less in Qishen group than that in model group. Conclusion Qishen Yiqi Gutta Pills can significantly improve heart function and inhibit ventricular remodeling in minipigs with myocardial ischemic heart failure induced by Ameroid constrictor.

Key words: Qishen Yiqi Gutta Pills, heart function, ventricular remodeling, minipigs

CLC Number: 

  • R289.5