主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (3): 171-174.doi: 10.3969/j.issn.1006-2157.2014.03.006

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Influences of Chinese medicinal with actions of regulating blood lipid and unblocking vessels on expressions of inflammatory cytokines in rabbits with atherosclerosis

ZHANG Lu1, SUN Qing1, GUO Shu-wen1, ZHENG Min2, ZHENG Cheng-long1, ZHANG Kuo3, FAN Ang-ran1, QI Xin1   

  1. 1 Beijing University of Chinese Medicine; Beijing 100029;
    2 China-Japan Friendship Hospital;
    3 Peking University Health Science Center
  • Received:2013-12-06 Online:2014-03-30 Published:2014-03-30

Abstract: Objective To investigate the mechanism of Chinese medicinal with actions of regulating blood lipid and unblocking vessels in regulating inflammatory cytokines in rabbits with atherosclerosis. Methods The rabbit model of atherosclerosis was established by using high fat diet and balloon injury method. The rabbits were randomly divided into normal group, model group, sham-operation group, atorvastatin group and Chinese medicinal group. The observations were carried out after treatment for 45 d and 90 d. The levels of serum C-reactive protein (CRP), transforming growth factor-β (TGF-β), interleukin-6 (IL-6), IL-10 and IL-17 were detected by applying enzyme-linked immunosorbent assay (ELISA). Results At different time points, the levels of serum CRP, IL-6 and IL-17 increased significantly (P<0.01) and TGF-β and IL-10 decreased significantly (P<0.01) in model group compared with sham-operation group. In Chinese medicinal group, the levels of serum IL-6, CRP and IL-17 decreased significantly (P<0.01) and TGF-β and IL-10 increased significantly (P<0.01) compared with model group, but had no difference compared with atorvastatin group. Conclusion The intervention of Chinese medicinal with actions of regulating blood lipid and unblocking vessels can significantly relieve atherosclerosis. The mechanism may be related to that the Chinese medicinal can reduce the levels of IL-6, CRP and IL-17, recover the structure and function of damaged endothelial cells, and abate the intimal lipid deposition in arterial wall.

Key words: Chinese medicinal with actions of regulating blood lipid and unblocking vessels, atherosclerosis, inflammatory cytokines, ELISA, rabbits

CLC Number: 

  • R289.51