主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (3): 180-183.doi: 10.3969/j.issn.1006-2157.2014.03.008

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Influences of Puerarin Injection on pathological changes of renal injury in KKAy mice with type 2 diabetes

XU Hong, YOU Hai-yan, LI Shu-yu, YI Yue-e, GAO Yu-shan, ZHANG Shu-jing, CAI Xin-lou, WANG Qian   

  1. Beijing University of Chinese Medicine, Beijing 100029
  • Received:2013-12-20 Online:2014-03-30 Published:2014-03-30

Abstract: Objective To study the effective mechanism of puerarin to diabetic nephropathy (DN). Methods Male KKAy mice (n=12, 14 weeks old) were randomly divided into model group and puerarin treatment group (treatment group, 1.3 mL/kg/d), and other 8 male C57BL/6J mice with the same age were included into normal group. On the 20th w and 24th w, the levels of plasma glucose, serum creatinine (Cr) and blood urea (BU) were detected in mice of all groups. On the 24th w, the mice were executed to collect kidney sample for observing renal pathological changes with light microscope and electron microscope. Results The levels of plasma glucose, serum Cr and BU decreased significantly in treatment group than those in model group (P<0.05 or P<0.01), the level of plasma glucose was significantly higher in treatment group than that in normal group (P<0.01), but levels of Cr and BU had no statistical difference. The morphological observation showed increased renal tubular mesangial cells and mesangial matrix, obvious vacuoles in cytoplasm of tubular epithelial cells and protein casts in renal tubules in model group. After the treatment with Puerarin Injection, all renal pathological changes were alleviated in treatment group. Conclusion Puerarin Injection can improve kidney function, abate renal pathological lesion and protect kidney in KKAy mice with type 2 diabetes.

Key words: KKAy mice, Puerarin Injection, diabetic nephropathy, pathological changes

CLC Number: 

  • R285.5