主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (4): 252-254.doi: 10.3969/j.issn.1006-2157.2014.04.009

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Effect of Compound Buguzhi Liniment on vitiligo in guinea pig model

YE Yi-lin1, TANG Jie1, LIU Qin2, ZHU Li-ran2, LI Li2   

  1. 1 College of Nursing, Anhui University of Traditional Chinese Medicine, Anhui 230038;
    2 Clinical College of Integrated Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine
  • Received:2013-06-13 Online:2014-04-30 Published:2014-04-30

Abstract: Objective To investigate the effect of Compound Buguzhi Liniment on vitiligo. Methods The model of vitiligo was established by using chemical decolorization and then treated with Compound Buguzhi Liniment in different doses. Compound Kaliziran Tincture was taken as a positive control drug. The influences of Compound Buguzhi Liniment on distribution of skin melanin and activities of cetylcholinesterase and tyrosinase were observed. Results Compound Buguzhi Liniment promoted skin pigmentation. The level of melanin increased significantly in basal layer cells and spinous layer cells, and hair follicles. The activities of cetylcholinesterase and tyrosinase were improved significantly. Conclusion Compound Buguzhi Liniment has a preventive and therapeutic effect on experimental vitiligo.

Key words: Compound Buguzhi Liniment, vitiligo, melanin, tyrosinase, guinea pigs

CLC Number: 

  • R285.5