主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (5): 309-313.doi: 10.3969/j.issn.1006-2157.2014.05.005

Previous Articles     Next Articles

Preventive effect of combined administration of extracts from Danggui (Radix Angelicae Sinensis) on colorectum cancer in mice

AN Jing, ZHAO Bo-chen, WU Qing, LAN Yi, CHEN Yan-yan, LIU Na, WANG Wen-ping   

  1. Beijing University of Chinses Medicine, Beijing 100102
  • Received:2013-11-08 Online:2014-05-30 Published:2014-05-30

Abstract: Objective To study the chemopreventive effect of combined administration of angelica polysaccharide (AP) and angelica oil (AO) from Danggui (Radix Angelicae Sinensis) on colorectum cancer in mice induced by azoxymethane/dextran sulfate sodium (AOM/DSS). Methods All mice were divided into model group, AO group, low-dose AP group, high-dose AP group, AO+low-dose AP group, AO+high-dose AP group and blank group. The incidence, size and number of colorectum cancer, and expressions of colorectum PCNA, COX-2 and iNOS were compared among all groups. Results AP and AO all had effects of reducing the incidence of colorectum cancer and inhibiting tumor development, which was the most significant in AO+high-dose AP group (compared with model group, P<0.05). The expressions of PCNA, COX-2 and iNOS decreased significantly in all drug groups (P<0.05 or P<0.01), which was the most significant in AO+high-dose AP group (compared with model group, P<0.05). Conclusion AP and AO all have preventive effect on colorectum cancer and their combined administration have a synergistic effect. The preventive effect of the combined administration of AP and AO on colorectum cancer may be related to they can reduce the expressions of PCNA, COX-2 and iNOS.

Key words: angelica polysaccharide, supercritical CO2 fluid extract from Danggui (Radix Angelicae Sinensis), colorectum cancer, cancer prevention, mice

CLC Number: 

  • R285.5